English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Beyond columnar organization: Horizontal pathways dominate cortical circuitry

Narayanan, R. T., Egger, R., Mohan, H., Johnson, A., Sakmann, B., de Kock, C., et al. (2014). Beyond columnar organization: Horizontal pathways dominate cortical circuitry. Poster presented at 44th Annual Meeting of the Society for Neuroscience (Neuroscience 2014), Washington, DC, USA.

Item is

Files

show Files

Locators

show
hide
Description:
-

Creators

show
hide
 Creators:
Narayanan, Rajeevan Therpurakal1, 2, Author              
Egger, Robert1, 2, Author              
Mohan, H, Author
Johnson, A, Author
Sakmann, B, Author
de Kock, C, Author
Oberlaender, Marcel1, 2, Author              
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Former Research Group Computational Neuroanatomy, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528698              

Content

show
hide
Free keywords: -
 Abstract: The cerebral cortex is organized into vertical elementary functional units, so called cortical columns. First described by Mountcastle et al., this concept has been most influential for studying the structure, function and computational principles of the mammalian cortex. However, evidence from multiple physiological and functional imaging studies suggested that vertical cortical signal flow is accompanied by horizontal spread. The anatomical basis of such trans-columnar processing remains yet unknown. Using the rodent vibrissal system as a model, we performed single neuron electrophysiological recordings/labeling in vivo. By doing so, we determined the complete three dimensional dendrite and axon projection patterns for a large set of excitatory neurons throughout cortical layers 2-6. Surprisingly, we found that horizontal axonal projections (i.e. outside the principal column) exceeded vertical projections. Moreover, horizontal pathways where not random, but reflected organizational principles of the peripheral receptor organs, i.e. the facial whiskers. Combining these striking novel anatomical data with functional recordings of whisker-evoked spiking activity, we integrated the reconstructed neurons into an anatomically detailed model of the rat barrel cortex and reverse engineered the cell-type specific cortical signal flow. We demonstrate that intracortical activation is based upon two excitatory pathways: a horizontal and a vertical one in deep and granular cortical layers, respectively. Our work shows that the current hypothesis of cortical organization needs to be revisited.

Details

show
hide
Language(s):
 Dates: 2014-11-17
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: BibTex Citekey: NarayananEMJSdO2014
 Degree: -

Event

show
hide
Title: 44th Annual Meeting of the Society for Neuroscience (Neuroscience 2014)
Place of Event: Washington, DC, USA
Start-/End Date: -

Legal Case

show

Project information

show

Source 1

show
hide
Title: 44th Annual Meeting of the Society for Neuroscience (Neuroscience 2014)
Source Genre: Proceedings
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: - Sequence Number: 440.01 Start / End Page: - Identifier: -