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Abstract:
MRS measurements in small, specific human brain regions with high clinical relevance for neuropsychiatric disorders are executed using non-water suppressed MRS enabling frequency and phase alignment of individual FIDs prior averaging. Results obtained from 16 healthy volunteers from the anterior cingulate cortex, the nucleus accumbens, the amygdala, and the occipital cortex show, that Creatine, N-acetyl-aspartate, glutamate and the combination of Glu and glutamine, choline and myo-inositol could be quantified reliably in group average spectra and by far the most individual data sets. This may promote better understanding of possible dysfunctions of brain metabolism and neurotransmission in neuropsychiatric disorders.
