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Abstract:
The aim of this investigation was to expand the number of predictive markers of in vivo MR spectroscopy measurements of the human spinal cord. Therefore, data was acquired in healthy volunteers with sophisticated motion and instability correction methods as well as advanced hardware enabling the acquisition with excellent spectral quality. Aspartate, Glutathione, and GABA could be additionally identified. In addition, for the first time, the findings were cross-validated with those retrieved from a cadaveric spinal cord sample using high resolution, magic angle spinning NMR measurements enabling a qualitative indication of the presence of the additional metabolite markers found in vivo.
