English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Altered brain diffusivity in Mild Cognitive Impairment: relationship with linguistic and semantic memory processes

Serra, L., Tuzzi, E., Gardini, S., Mitolo, M., Bechi Gabrielli, G., Fasano, F., et al. (2014). Altered brain diffusivity in Mild Cognitive Impairment: relationship with linguistic and semantic memory processes. Poster presented at IX Congresso Sindem Italian Association for the Study of Dementia linked to the Italian Neurological Society, Firenze, Italy.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0001-3319-A Version Permalink: http://hdl.handle.net/21.11116/0000-0001-375F-8
Genre: Poster

Files

show Files

Creators

show
hide
 Creators:
Serra, L, Author
Tuzzi, Elisa1, Author              
Gardini, S, Author
Mitolo, M, Author
Bechi Gabrielli, G, Author
Fasano, F, Author
Giulietti, G, Author
Bozzali, M, Author
Caffarra, P, Author
Affiliations:
1External Organizations, ou_persistent22              

Content

show
hide
Free keywords: -
 Abstract: Background: Microstructural abnormalities on diffusion tensor imaging (DTI) are promising in vivo biomarkers of brain changes associated with the progression of Alzheimer’s Dementia pathology. Recent studies indicate that a decrease of white matter integrity has been found in Mild Cognitive Impairment (MCI) defi ned as a prodromal condition for AD. Objectives: The present study aimed to investigate the brain diffusivity changes in MCI quantifi ed as fractional anisotropy (FA) and mean diffusivity (MD), and to evaluate if the changes in white matter diffusivity are related to linguistic and semantic memory processes. Methods: Eighteen healthy elderly and 22 MCI patients were enrolled in this study. All participants underwent 3T MRI exam for diffusion tensor based white matter investigation and cognitive tests of visual naming, naming from definition, categorical fluency and reading for objects, actions and famous people, and words-association. The comparison of FA and MD between groups and correlations between them and cognitive performance in MCI were carried out. Results: There were no group differences in FA, but there was a hemispheric lateralization effect, such as a decreased FA on the right hemisphere compared to the left one. Compared to healthy elderly, MCI patients showed a reduced mean FA in the right inferior longitudinal fasciculus (ILF) and elevated MD in the uncinate fasciculus (UNC), suggestive of a neuronal loss in these tracts. Moreover, the FA of the ILF correlated with the reading of action performance, confirming the role of ILF in language and visual identification processes. Conclusions: Our findings evidenced that MCI presents white matter diffusivity alterations in ILF and UNC, which might underling cognitive impairment. Across the linguistic and semantic variables, reading of action appeared to be related to ILF FA, forthcoming studies will encompass also other cognitive abilities.

Details

show
hide
Language(s):
 Dates: 2014-03
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.3233/JAD-149999
BibTex Citekey: SerraTGMBFGBC2014
 Degree: -

Event

show
hide
Title: IX Congresso Sindem Italian Association for the Study of Dementia linked to the Italian Neurological Society
Place of Event: Firenze, Italy
Start-/End Date: -

Legal Case

show

Project information

show

Source 1

show
hide
Title: Journal of Alzheimer's Disease
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 41 (s2) Sequence Number: - Start / End Page: S51 Identifier: -