English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Push limits and extend boundaries of small animal fMRI

Yu, X. (2014). Push limits and extend boundaries of small animal fMRI. Talk presented at Athinoula A. Martinos Center for Biomedical Imaging. Charlestown, MA, USA. 2014-07-30.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0001-339A-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-734A-8
Genre: Talk

Files

show Files

Creators

show
hide
 Creators:
Yu, X1, 2, Author              
Affiliations:
1Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528695              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

Content

show
hide
Free keywords: -
 Abstract: In this talk, I will first describe our effort to push the spatiotemporal limit of fMRI in the rodent brain. We developed a line-scanning fMRI method to demonstrate the laminar position of fMRI onset coincides with distinct neural inputs to the cortex (Yu et al. Nature Methods, 2014). Here, we acquired the fMRI signal across cortical depth in 50µm spatial resolution with 50ms sampling rate. Furthermore, we improved the method to image the BOLD and CBV fMRI signal from individual penetrating venules and arterioles across the cortex with 100x100µm spatial resolution and 100ms sampling rate. This work allows us to decipher the vascular contribution to the neurovascular coupling in the deep layer cortex. However, to provide specific neural control underlying the coupled vascular response, we need to elicit activity through different components across the vascular neural network. In the second part of my talk, I will show our recent effort to implement the fiber-optic insertion to drive activity through different neural circuit. The goal of the future work is to decipher the molecular, cellular, and neural-vascular circuit of the neurovascular coupling underlying fMRI.

Details

show
hide
Language(s):
 Dates: 2014-07
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: BibTex Citekey: Yu2014_6
 Degree: -

Event

show
hide
Title: Athinoula A. Martinos Center for Biomedical Imaging
Place of Event: Charlestown, MA, USA
Start-/End Date: 2014-07-30
Invited: Yes

Legal Case

show

Project information

show

Source

show