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Schlagwörter:
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Zusammenfassung:
In this multimodal, double-blind, randomized, placebo-controlled PET-MRS study in 20 healthy subjects, we report a pharmacological modulation of glutamate-dependent neuroreceptor plasticity in the pregenual anterior cingulate cortex following the administration of the NMDA-receptor antagonist ketamine. In order to investigate the functional interplay between the major excitatory neurotransmitter glutamate (Glu) and the density of the metabotropic glutamate receptor subtype 5 (mGluR5) we combined proton magnetic resonance spectroscopy (1H-MRS) with positron emission tomography (11C-ABP688-PET). Our findings complement previous reports of increased glutamate release during ketamine challenge by providing additional in vivo molecular imaging evidence for ketamine-induced neurotransmitter-receptor coupling.
