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  Multimodal PET-MRS Investigation of Glutamate-Dependent Neuroreceptor Plasticity in the Healthy Human Brain

Scheidegger, M., Fuchs, A., Ametamey, S., Kuhn, F., Johayem, A., Buck, A., et al. (2014). Multimodal PET-MRS Investigation of Glutamate-Dependent Neuroreceptor Plasticity in the Healthy Human Brain. In Joint Annual Meeting ISMRM-ESMRMB 2014.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0001-33F5-1 Version Permalink: https://hdl.handle.net/21.11116/0000-0001-3734-7
Genre: Meeting Abstract

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http://www.ismrm.org/14/program_files/Session37.htm (Abstract)
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 Creators:
Scheidegger, M, Author
Fuchs, A, Author
Ametamey, S, Author
Kuhn, F, Author
Johayem, A, Author
Buck, A, Author
Seifritz, E, Author
Henning, Anke1, 2, Author           
Affiliations:
1Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528692              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: In this multimodal, double-blind, randomized, placebo-controlled PET-MRS study in 20 healthy subjects, we report a pharmacological modulation of glutamate-dependent neuroreceptor plasticity in the pregenual anterior cingulate cortex following the administration of the NMDA-receptor antagonist ketamine. In order to investigate the functional interplay between the major excitatory neurotransmitter glutamate (Glu) and the density of the metabotropic glutamate receptor subtype 5 (mGluR5) we combined proton magnetic resonance spectroscopy (1H-MRS) with positron emission tomography (11C-ABP688-PET). Our findings complement previous reports of increased glutamate release during ketamine challenge by providing additional in vivo molecular imaging evidence for ketamine-induced neurotransmitter-receptor coupling.

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 Dates: 2014-05
 Publication Status: Issued
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 Identifiers: BibTex Citekey: ScheideggerFAKJBSH2014
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Title: Joint Annual Meeting ISMRM-ESMRMB 2014
Place of Event: Milano, Italy
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Title: Joint Annual Meeting ISMRM-ESMRMB 2014
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 0457 Start / End Page: - Identifier: -