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  Lateral geniculate neurons projecting to primary visual cortex show ocular dominance plasticity in adult mice

Jaepel, J., Hübener, M., Bonhoeffer, T., & Rose, T. (2017). Lateral geniculate neurons projecting to primary visual cortex show ocular dominance plasticity in adult mice. Nature Neuroscience, 20, 1708-1714. doi:10.1038/s41593-017-0021-0.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-3D3D-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-3D3E-7
Genre: Journal Article

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 Creators:
Jaepel, Juliane1, Author              
Hübener, Mark1, Author              
Bonhoeffer, Tobias1, Author              
Rose, Tobias1, Author              
Affiliations:
1Department: Synapses-Circuits-Plasticity / Bonhoeffer, MPI of Neurobiology, Max Planck Society, ou_1113545              

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Free keywords: Cortex; Thalamus
 Abstract: Experience-dependent plasticity in the mature visual system is widely considered to be cortical. Using chronic two-photon Ca2+ imaging of thalamic afferents in layer 1 of binocular visual cortex, we provide evidence against this tenet: the respective dorsal lateral geniculate nucleus (dLGN) cells showed pronounced ocular dominance (OD) shifts after monocular deprivation in adult mice. Most (86%), but not all, of dLGN cell boutons were monocular during normal visual experience. Following deprivation, initially deprived-eye-dominated boutons reduced or lost their visual responsiveness to that eye and frequently became responsive to the non-deprived eye. This cannot be explained by eye-specific cortical changes propagating to dLGN via cortico-thalamic feedback because the shift in dLGN responses was largely resistant to cortical inactivation using the GABAA receptor agonist muscimol. Our data suggest that OD shifts observed in the binocular visual cortex of adult mice may at least partially reflect plasticity of eye-specific inputs onto dLGN neurons.

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 Dates: 2017-11-13
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1038/s41593-017-0021-0
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Project name : grant SFB870
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Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft

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Title: Nature Neuroscience
  Other : Nat. Neurosci.
Source Genre: Journal
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Publ. Info: New York, NY : Nature America Inc.
Pages: - Volume / Issue: 20 Sequence Number: - Start / End Page: 1708 - 1714 Identifier: ISSN: 1097-6256
CoNE: /journals/resource/954925610931