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  A systems medicine research approach for studying alcohol addiction

Spanagel, R., Durstewitz, D., Hansson, A., Heinz, A., Kiefer, F., Köhr, G., et al. (2013). A systems medicine research approach for studying alcohol addiction. Addiction Biology, 18(6), 883-896. doi:10.1111/adb.12109.

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 Creators:
Spanagel, R, Author
Durstewitz, D, Author
Hansson, A, Author
Heinz, A, Author
Kiefer, F, Author
Köhr, G, Author
Matthäus, F, Author
Nöthen, MM, Author
Noori, Hamid R1, Author              
Obermayer, K, Author
Rietschel, M, Author
Schloss, P, Author
Scholz, H, Author
Schumann, G, Author
Smolka, M, Author
Sommer, W, Author
Vengeliene, V, Author
Walter, H, Author
Wurst, W, Author
Zimmermann, US, Author
Stringer, S, AuthorSmits, Y, AuthorDerks , EM, Author more..
Affiliations:
1Insitute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, ou_persistent22              

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 Abstract: According to the World Health Organization, about 2 billion people drink alcohol. Excessive alcohol consumption can result in alcohol addiction, which is one of the most prevalent neuropsychiatric diseases afflicting our society today. Prevention and intervention of alcohol binging in adolescents and treatment of alcoholism are major unmet challenges affecting our health‐care system and society alike. Our newly formed German SysMedAlcoholism consortium is using a new systems medicine approach and intends (1) to define individual neurobehavioral risk profiles in adolescents that are predictive of alcohol use disorders later in life and (2) to identify new pharmacological targets and molecules for the treatment of alcoholism. To achieve these goals, we will use omics‐information from epigenomics, genetics transcriptomics, neurodynamics, global neurochemical connectomes and neuroimaging (IMAGEN; Schumann et al. 2010) to feed mathematical prediction modules provided by two Bernstein Centers for Computational Neurosciences (Berlin and Heidelberg/Mannheim), the results of which will subsequently be functionally validated in independent clinical samples and appropriate animal models. This approach will lead to new early intervention strategies and identify innovative molecules for relapse prevention that will be tested in experimental human studies. This research program will ultimately help in consolidating addiction research clusters in Germany that can effectively conduct large clinical trials, implement early intervention strategies and impact political and healthcare decision makers.

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 Dates: 2013-11
 Publication Status: Published in print
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 Identifiers: DOI: 10.1111/adb.12109
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Title: Addiction Biology
Source Genre: Journal
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Pages: - Volume / Issue: 18 (6) Sequence Number: - Start / End Page: 883 - 896 Identifier: -