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  Why do proteases mess up with antigen presentation by re-shuffling antigen sequences?

Liepe, J., Ovaa, H., & Mishto, M. (2018). Why do proteases mess up with antigen presentation by re-shuffling antigen sequences? Current Opinion in Immunology, 52, 81-86. doi:10.1016/j.coi.2018.04.016.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-44ED-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-8652-9
Genre: Journal Article

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 Creators:
Liepe, J.1, Author              
Ovaa, H., Author
Mishto, M., Author
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1Research Group of Quantitative and System Biology, MPI for Biophysical Chemistry, Max Planck Society, ou_2466694              

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 Abstract: The sequence of a large number of MHC-presented epitopes is not present as such in the original antigen because it has been re-shuffled by the proteasome or other proteases. Why do proteases throw a spanner in the works of our model of antigen tagging and immune recognition? We describe in this review what we know about the immunological relevance of post-translationally spliced epitopes and why proteases seem to have a second (dark) personality, which is keen to create new peptide bonds.

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Language(s): eng - English
 Dates: 2018-04-302018-06-01
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.coi.2018.04.016
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Title: Current Opinion in Immunology
Source Genre: Journal
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Pages: - Volume / Issue: 52 Sequence Number: - Start / End Page: 81 - 86 Identifier: -