English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Zbtb20 regulates developmental neurogenesis in the olfactory bulb and gliogenesis after adult brain injury.

Doeppner, T. R., Herz, J., Bähr, M., Tonchev, A. B., & Stoykova, A. (2019). Zbtb20 regulates developmental neurogenesis in the olfactory bulb and gliogenesis after adult brain injury. Molecular Neurobiology, 56(1), 567-582. doi:10.1007/s12035-018-1104-y.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0001-47AC-E Version Permalink: http://hdl.handle.net/21.11116/0000-0003-4A7B-1
Genre: Journal Article

Files

show Files
hide Files
:
2586371.pdf (Publisher version), 24MB
 
File Permalink:
-
Name:
2586371.pdf
Description:
-
Visibility:
Restricted ( Max Planck Society (every institute); )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-
:
2586371_Suppl.1007_s12035-018-1104-y (Supplementary material), 230KB
Name:
2586371_Suppl.1007_s12035-018-1104-y
Description:
-
Visibility:
Public
MIME-Type / Checksum:
text/html / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Doeppner, T. R., Author
Herz, J., Author
Bähr, M., Author
Tonchev, A. B., Author
Stoykova, A.1, Author              
Affiliations:
1Research Group of Molecular Developmental Neurobiology, MPI for biophysical chemistry, Max Planck Society, ou_578587              

Content

show
hide
Free keywords: Zbtb20; Olfactory bulb; Post-natal progenitor cell; Astrocyte; Stroke
 Abstract: The transcription factor (TF) Zbtb20 is important for the hippocampal specification and the regulation of neurogenesis of neocortical projection neurons. Herein, we show a critical involvement of the TF Zbtb20 in the neurogenesis of both projection neurons and interneurons of the olfactory bulb during embryonic stages. Our data indicate that the lack of Zbtb20 significantly diminishes the generation of a set of early-born Tbr2+ neurons during embryogenesis. Furthermore, we provide evidence that Zbtb20 regulates the transition between neurogenesis to gliogenesis in cortical radial glial progenitor cells at the perinatal (E18.5) stage. In the adult mammalian brain, Zbtb20 is expressed by GFAP+ neural progenitor cells (NPCs) located in the forebrain neurogenic niche, i.e., the subventricular zone (SVZ) of the lateral ventricles. Upon induction of cerebral ischemia, we found that Zbtb20 expression is upregulated in astrocytic-like cells, whereas diminishing the expression levels of Zbtb20 significantly reduces the ischemia-induced astrocytic reaction as observed in heterozygous Zbtb20 loss-of-function mice. Altogether, these results highlight the important role of the TF Zbtb20 as a temporal regulator of neurogenesis or gliogenesis, depending on the developmental context.

Details

show
hide
Language(s): eng - English
 Dates: 2018-05-112019-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1007/s12035-018-1104-y
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Molecular Neurobiology
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 56 (1) Sequence Number: - Start / End Page: 567 - 582 Identifier: -