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  elective homonuclear polarization transfer for spectroscopic imaging of GABA at 7T

Pan, J., Duckrow, R., Spencer, D., Avdievich, N., & Hetherington, H. (2013). elective homonuclear polarization transfer for spectroscopic imaging of GABA at 7T. Magnetic Resonance in Medicine, 69(2), 310-316. doi:10.1002/mrm.24283.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-484E-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-484F-7
Genre: Journal Article

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Pan, JW, Author
Duckrow, RB, Author
Spencer, DD, Author
Avdievich, Nikolai1, Author              
Hetherington, HP, Author
Affiliations:
1Department of Neurosurgery, Yale University, New Haven, Connecticut, USA, ou_persistent22              

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 Abstract: We develop and implement a selective homonuclear polarization transfer method for the detection of 3.0 ppm C‐4 GABA resonance by spectroscopic imaging in the human brain at 7T. This single shot method is demonstrated with simulations and phantoms, which achieves comparable efficiency of detection to that of J‐difference editing. The macromolecule resonance that commonly co‐edits with GABA is suppressed at 7T through use of a narrow band preacquisition suppression pulse. This technique is implemented in humans with an eight channel transceiver array and high degree B0 shimming to measure supplementary motor area and thalamic GABA in controls (n = 8) and epilepsy patients (n = 8 total). We find that the GABA/N‐acetyl aspartate ratio in the thalamus of control volunteers, well controlled and poorly controlled epilepsy patients are 0.053 ± 0.012 (n = 8), 0.090 ± 0.012 (n = 2), and 0.038 ± 0.009 (n = 6), respectively.

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 Dates: 2013-02
 Publication Status: Published in print
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 Identifiers: DOI: 10.1002/mrm.24283
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Title: Magnetic Resonance in Medicine
Source Genre: Journal
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Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: 69 (2) Sequence Number: - Start / End Page: 310 - 316 Identifier: ISSN: 0740-3194
CoNE: /journals/resource/954925538149