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  Spikes in Mammalian Bipolar Cells Support Temporal Layering of the Inner Retina

Baden, T., Berens, P., Bethge, M., & Euler, T. (2013). Spikes in Mammalian Bipolar Cells Support Temporal Layering of the Inner Retina. Current Biology, 23(1), 48-52. doi:10.1016/j.cub.2012.11.006.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-49CC-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-49CD-7
Genre: Journal Article

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Baden, T, Author
Berens, Philipp, Author              
Bethge, Matthias1, 2, Author              
Euler, T, Author
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Research Group Computational Vision and Neuroscience, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497805              

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 Abstract: In the mammalian retina, 10–12 different cone bipolar cell (BC) types decompose the photoreceptor signal into parallel channels [1–8], providing the basis for the functional diversity of retinal ganglion cells (RGCs) [9]. BCs differing in their temporal properties appear to project to different strata of the retina’s inner synaptic layer [10, 11], based on somatic recordings of BCs [1, 2, 4, 12–14] and excitatory synaptic currents measured in RGCs [10]. However, postsynaptic currents in RGCs are influenced by dendritic morphology [15, 16] and receptor types [17], and the BC signal can be transformed at the axon terminals both through interactions with amacrine cells [18, 19] and through the generation of all-or-nothing spikes [20–24]. Therefore, the temporal properties of the BC output have not been analyzed systematically across different types of mammalian BCs. We recorded calcium signals directly within axon terminals using two-photon imaging [25, 26] and show that BCs can be divided into ≥eight functional clusters. The temporal properties of the BC output were directly reflected in their anatomical organization within the retina’s inner synaptic layer: faster cells stratified closer to the border between ON and OFF sublamina. Moreover, ≥three fastest groups generated clear all-or-nothing spikes. Therefore, the systematic projection pattern of BCs provides distinct temporal “building blocks” for the feature extracting circuits of the inner retina.

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 Dates: 2013-01
 Publication Status: Published in print
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 Identifiers: DOI: 10.1016/j.cub.2012.11.006
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Title: Current Biology
  Other : Curr. Biol.
Source Genre: Journal
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Publ. Info: London, UK : Cell Press
Pages: - Volume / Issue: 23 (1) Sequence Number: - Start / End Page: 48 - 52 Identifier: ISSN: 0960-9822
CoNE: /journals/resource/954925579107