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  Development and use of tube tetrodes for electrophysiological investigation of deep lying brain structures of the macaque

Kapoor, V. (2013). Development and use of tube tetrodes for electrophysiological investigation of deep lying brain structures of the macaque. In Donders Discussions 2013 (pp. 20).

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-4EB5-C Version Permalink: http://hdl.handle.net/21.11116/0000-0001-58D8-9
Genre: Meeting Abstract

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Kapoor, V1, 2, Author              
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1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              

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 Abstract: A major approach of investigation in systems neuroscience has been to study the activity of single neurons (units) in relation to a sensory input or a behavioral act. One tool, which has been consistently employed for this purpose is the microelectrode. Recent advances in microelectrode technology have permitted recording the activity of several neurons simultaneously, therefore allowing the study of information processing at the level of neuronal populations. Twisted wire tetrodes (TWTs), have played an instrumental role in this advance because of their ability to record multiple single units and the isolation quality of the recorded single units. However, their limited tensile strength has hindered their use for electrophysiological recordings in deep lying structures of the macaque brain. We therefore developed a simple method for conferring strength to conventional TWTs, and call them Tube Tetrodes (TuTes). TuTes can be built using standard laboratory equipment and are very cost efficient. Further, their ultrathin diameter minimizes the tissue damage along their path. We also developed a multi-tetrode drive to independently control and advance up to 5 TuTes to the inferotemporal cortex of a rhesus macaque. Electrophysiological activity recorded with these TuTes from a macaque engaged in a simple behavioral task demonstrates that the signal quality recorded from them is comparable to conventional TWTs. Finally, these TuTes could be easily adapted to work with other microdrives commonly used for electrophysiology.

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 Dates: 2013-10
 Publication Status: Published in print
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 Identifiers: BibTex Citekey: Kapoor2013_2
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Title: Donders Discussions 2013
Place of Event: Nijmegen, The Netherlands
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Title: Donders Discussions 2013
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 20 Identifier: -