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  Improving Spectral Quality in the Myocardium at 3T Using ECG- Triggered, Navigator-Gated Metabolite-Cycling along with Image-Based B0-Shimming

Fillmer, A., Cameron, D., Hock, A., Redpath, T., Frenneaux, M., Dawson, D., et al. (2013). Improving Spectral Quality in the Myocardium at 3T Using ECG- Triggered, Navigator-Gated Metabolite-Cycling along with Image-Based B0-Shimming. Magnetic Resonance Materials in Physics, Biology and Medicine, 26(Supplement 1), 62-63.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-5182-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-5183-F
Genre: Meeting Abstract

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 Creators:
Fillmer, A, Author
Cameron, D, Author
Hock, A, Author
Redpath, T, Author
Frenneaux, M, Author
Dawson, D, Author
Henning, A1, 2, Author              
Affiliations:
1Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528692              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: 1H MR Spectroscopy is a promising tool for investigating heart disease. To achieve a good spectral quality, challenges like cardiac and respiratory motion and complex B0-field inhomogeneities must be addressed. The combination of image-based B0-shimming[1], ECG-triggering and navigator-gating[2] along with frequency-alignment and phase-correction of metabolite-cycled )[3], non-water-suppressed MRS[4] data, is used to demonstrate the feasibility of metabolite-cycling in the heart. Measurements were performed in five volunteers(21y- 39y) on an Achieva 3T system with a 6-element cardiac coil (Philips Healthcare,Best,NL). Navigator-gated bSSFP cine images (fig.(1)) were used for positioning the spectroscopy voxel (40x20x10mm3) in the interventricular septum and establishing the trigger delay. For B0-shimming an image-based ‘ShimTool’[1,5] was employed. Calibration and PRESS sequences (min.TR=2500ms,TE=41ms,acq.time=512ms) were ECG-triggered to end-systole and navigator-gated, with a large gating-window during acquisitions. To mitigate spectral contamination from outside the VOI, a previously implemented[6] inner-volume-saturation (IVS)[7] scheme was used. For comparison MC PRESS was performed with 256NSA in 4 volunteers and with 512NSA in a fifth volunteer, in whom a 256NSA WS PRESS spectrum was also acquired. The MC FIDs from the 512 NSA acquisition were post-processed in 3 different ways using MRecon(Gyrotools,Zurich,CH): (i) frequency-aligned, phase- and navigator-corrected; (ii)navigator-corrected only; (iii)not corrected. All other acquisitions were fully motion-corrected. Fig.(2) demonstrates the effect of frequency-alignment and phase-correction.

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 Dates: 2013-10
 Publication Status: Published in print
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 Identifiers: DOI: 10.1007/s10334-013-0382-7
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Title: 30th Annual Scientific Meeting ESMRMB 2013
Place of Event: Toulouse, France
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Title: Magnetic Resonance Materials in Physics, Biology and Medicine
Source Genre: Journal
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Pages: - Volume / Issue: 26 (Supplement 1) Sequence Number: - Start / End Page: 62 - 63 Identifier: -