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  Otoconia: Mimicking a calcite-based functional material of the human body. From basic research to medical aspects

Kniep, R. (2015). Otoconia: Mimicking a calcite-based functional material of the human body. From basic research to medical aspects. Pure and Applied Chemistry, 87(8), 719-736. doi:10.1515/pac-2015-0201.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-5264-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-5266-0
Genre: Journal Article

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 Creators:
Kniep, Rüdiger1, Author              
Affiliations:
1Rüdiger Kniep, Inorganic Chemistry, Max Planck Institute for Chemical Physics of Solids, Max Planck Society, ou_1863437              

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 Abstract: Otoconia (calcite-based biominerals) are part of the sensory system in the inner ear of vertebrates, acting as gravity receptors responding to linear accelerations. Biomimetic otoconia are grown by double-diffusion into gelatine-gel matrices, and represent the first example of successful imitation of a biomineral, not only in outer shape but also in composite structure and hierarchical inner architecture. Biomimetic and biogenic (human) otoconia are investigated by X-ray methods, chemical analytics, ESEM, and TEM. Shape development (morphogenesis) as well as (partial) dissolution of the calcite component of the composite underline the hierarchical inner architecture built of more dense rhombohedral branches (with plane end-faces) and a rounded, more porous belly area. Atomistic simulations are performed in order to get insight into very first nucleation steps. Based on the detailed observations made up to now, first assumptions for the function of otoconia are developed, including the questions of density distribution within the volume of the specimen, the surrounding endolymph, as well as anchoring and interconnections of otoconia. A final point concerns the degeneration of otoconia which is caused by complexing agents and/or changes in ion concentrations (and pH) of the endolymph.

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Language(s): eng - English
 Dates: 2015-06-022015-06-02
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: ISI: 000359014500002
DOI: 10.1515/pac-2015-0201
 Degree: -

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Title: Pure and Applied Chemistry
  Other : Pure Appl. Chem.
Source Genre: Journal
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Publ. Info: Oxford : International Union of Pure and Applied Chemistry.
Pages: - Volume / Issue: 87 (8) Sequence Number: - Start / End Page: 719 - 736 Identifier: ISSN: 0033-4545
CoNE: https://pure.mpg.de/cone/journals/resource/954925436486