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  Amide proton chemical exchange saturation transfer at 9.4 T

Mirkes, C., Shajan, G., Hoffmann, J., & Scheffler, K. (2013). Amide proton chemical exchange saturation transfer at 9.4 T. Contrast Media & Molecular Imaging, 8(3), 311-312.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0001-5570-1 Version Permalink: https://hdl.handle.net/21.11116/0000-0003-4518-5
Genre: Meeting Abstract

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http://onlinelibrary.wiley.com/doi/10.1002/cmmi.1522/epdf (Publisher version)
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 Creators:
Mirkes, C1, 2, Author           
Shajan, G1, 2, Author           
Hoffmann, J1, 2, Author           
Scheffler, K1, 2, Author           
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: The backbone amide groups in peptides and proteins [1] are one of many endogenous compounds able to exhibit a chemical exchange saturation transfer (CEST) effect by exchanging protons with water molecules. The resonance frequency of the amide protons is situated at 3.6 ppm from the water resonance frequency.
Unfortunately, the quantification of the amide proton transfer (APT) effect using a standard asymmetry analysis
approach is hindered by the nuclear Overhauser effect (NOE) at upfield frequencies (e.g. -3.6 ppm). Very recently [2] it has been shown that in rat brain the APT effect and the NOE can be directly discriminated at ultrahigh magnetic field due to the concomitant wide spectral separation. In this initial work we demonstrate that it is possible to acquire amide proton CEST spectra in the human brain at 9.4 T.

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 Dates: 2013-05
 Publication Status: Issued
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 Identifiers: DOI: 10.1002/cmmi.1522
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Title: 3rd International Workshop on Chemical Exchange Saturation Transfer Imaging (OctoberCEST 2012)
Place of Event: Annapolis, MD, USA
Start-/End Date: 2012-10-15 - 2012-10-17

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Title: Contrast Media & Molecular Imaging
Source Genre: Journal
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Publ. Info: Hoboken, NJ : Wiley-Blackwell
Pages: - Volume / Issue: 8 (3) Sequence Number: - Start / End Page: 311 - 312 Identifier: ISSN: 1555-4309
CoNE: https://pure.mpg.de/cone/journals/resource/1555-4309