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  Epigenetic regulation by BAF complexes limits neural stem cell proliferation by suppressing Wnt signaling in late embryonic development.

Nguyen, H., Kerimoglu, C., Pirouz, M., Pham, L., Kiszka, K. A., Sokpor, G., et al. (2018). Epigenetic regulation by BAF complexes limits neural stem cell proliferation by suppressing Wnt signaling in late embryonic development. Stem Cell Reports, 10(6), 1734-1750. doi:10.1016/j.stemcr.2018.04.014.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-5588-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-AE4A-9
Genre: Journal Article

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 Creators:
Nguyen, H., Author
Kerimoglu, C., Author
Pirouz, M.1, Author              
Pham, L., Author
Kiszka, K. A., Author
Sokpor, G., Author
Sakib, M. S., Author
Rosenbusch, J., Author
Teichmann, U.2, Author              
Seong, R. H., Author
Stoykova, A.3, Author              
Fischer, A., Author
Staiger, J. F., Author
Tuoc, T., Author
Affiliations:
1Research Group of Developmental Biology, MPI for Biophysical Chemistry, Max Planck Society, ou_578586              
2Animal Facility, MPI for Biophysical Chemistry, Max Planck Society, ou_2355695              
3Research Group of Molecular Developmental Neurobiology, MPI for biophysical chemistry, Max Planck Society, ou_578587              

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Free keywords: BAF (mSWI/SNF) complexes; H3K27me3; H3K4me2; chromatin remodeling; cortical development; epigenetics; hippocampal development; neural stem cells; neurogenesis
 Abstract: During early cortical development, neural stem cells (NSCs) divide symmetrically to expand the progenitor pool, whereas, in later stages, NSCs divide asymmetrically to self-renew and produce other cell types. The timely switch from such proliferative to differentiative division critically determines progenitor and neuron numbers. However, the mechanisms that limit proliferative division in late cortical development are not fully understood. Here, we show that the BAF (mSWI/SNF) complexes restrict proliferative competence and promote neuronal differentiation in late corticogenesis. Inactivation of BAF complexes leads to H3K27me3-linked silencing of neuronal differentiation-related genes, with concurrent H3K4me2-mediated activation of proliferation-associated genes via de-repression of Wnt signaling. Notably, the deletion of BAF complexes increased proliferation of neuroepithelial cell-like NSCs, impaired neuronal differentiation, and exerted a Wnt-dependent effect on neocortical and hippocampal development. Thus, these results demonstrate that BAF complexes act as both activators and repressors to control global epigenetic and gene expression programs in late corticogenesis.

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Language(s): eng - English
 Dates: 2018-05-082018-06-05
 Publication Status: Published in print
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.stemcr.2018.04.014
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Title: Stem Cell Reports
Source Genre: Journal
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Pages: - Volume / Issue: 10 (6) Sequence Number: - Start / End Page: 1734 - 1750 Identifier: -