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Abstract:
Cardiac 1H MRS can be used assess myocardial lipid content and to investigate pathophysiologies, but spectral quality is severely limited by cardiac and respiratory motion, as well as static field inhomogeneities, which are especially challenging at higher field strengths. In this work, ECG-triggering, navigator-gating, frequency alignment and phase correction are combined, for the first time, with a metabolite-cycled 1H cardiac MRS method and an improved ‘Localised B0 Shimming Tool’ to produce superlative motion compensation at 3T. Resulting spectra, acquired in 5 volunteers, show superior quality to others reported at this field strength (e.g. CH2 lipid SNR=28, FWHM=25, CRLB=1.8%).
