English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
  Drosophila as a model for ageing

Piper, M. D. W., & Partridge, L. (2017). Drosophila as a model for ageing. Biochim Biophys Acta. doi:10.1016/j.bbadis.2017.09.016.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0001-5922-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-5923-4
Genre: Journal Article

Files

show Files

Locators

show
hide
Description:
-

Creators

show
hide
 Creators:
Piper, M. D. W.1, Author
Partridge, L.1, Author
Affiliations:
1Max Planck Institute for Biology of Ageing, Max Planck Society, Joseph-Stelzmann-Str. 9b, D-50931 Cologne, DE, ou_1942284              

Content

show
hide
Free keywords: Ageing Dietary restriction Drosophila Insulin signaling Tor Tissue control of ageing
 Abstract: Drosophila melanogaster has been a key model in developing our current understanding of the molecular mechanisms of ageing. Of particular note is its role in establishing the evolutionary conservation of reduced insulin and IGF-1-like signaling in promoting healthy ageing. Capitalizing on its many advantages for experimentation, more recent work has revealed how precise nutritional and genetic interventions can improve fly lifespan without obvious detrimental side effects. We give a brief summary of these recent findings as well as examples of how they may modify ageing via actions in the gut and muscle. These discoveries highlight how expanding our understanding of metabolic and signaling interconnections will provide even greater insight into how these benefits may be harnessed for anti-ageing interventions.

Details

show
hide
Language(s):
 Dates: 2017
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: Other: 28964875
DOI: 10.1016/j.bbadis.2017.09.016
ISSN: 0006-3002 (Print)0006-3002 (Linking)
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Biochim Biophys Acta
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: -