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  A proteomic atlas of insulin signalling reveals tissue-specific mechanisms of longevity assurance

Tain, L. S., Sehlke, R., Jain, C., Chokkalingam, M., Nagaraj, N., Essers, P., et al. (2017). A proteomic atlas of insulin signalling reveals tissue-specific mechanisms of longevity assurance. Mol Syst Biol, 13(9), 939. doi:10.15252/msb.20177663.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-0001-5932-3 Versions-Permalink: https://hdl.handle.net/21.11116/0000-0001-5933-2
Genre: Zeitschriftenartikel

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externe Referenz:
https://www.ncbi.nlm.nih.gov/pubmed/28916541 (beliebiger Volltext)
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 Urheber:
Tain, L. S.1, Autor
Sehlke, R.1, Autor
Jain, C.1, Autor
Chokkalingam, M.1, Autor
Nagaraj, N.1, Autor
Essers, P.1, Autor
Rassner, M.1, Autor
Gronke, S.1, Autor
Froelich, J.1, Autor
Dieterich, C.1, Autor
Mann, M.1, Autor
Alic, N.1, Autor
Beyer, A.1, Autor
Partridge, L.1, Autor
Affiliations:
1Max Planck Institute for Biology of Ageing, Max Planck Society, Joseph-Stelzmann-Str. 9b, D-50931 Cologne, DE, ou_1942284              

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Schlagwörter: ageing insulin/IGF mitochondria proteasome proteome
 Zusammenfassung: Lowered activity of the insulin/IGF signalling (IIS) network can ameliorate the effects of ageing in laboratory animals and, possibly, humans. Although transcriptome remodelling in long-lived IIS mutants has been extensively documented, the causal mechanisms contributing to extended lifespan, particularly in specific tissues, remain unclear. We have characterized the proteomes of four key insulin-sensitive tissues in a long-lived Drosophila IIS mutant and control, and detected 44% of the predicted proteome (6,085 proteins). Expression of ribosome-associated proteins in the fat body was reduced in the mutant, with a corresponding, tissue-specific reduction in translation. Expression of mitochondrial electron transport chain proteins in fat body was increased, leading to increased respiration, which was necessary for IIS-mediated lifespan extension, and alone sufficient to mediate it. Proteasomal subunits showed altered expression in IIS mutant gut, and gut-specific over-expression of the RPN6 proteasomal subunit, was sufficient to increase proteasomal activity and extend lifespan, whilst inhibition of proteasome activity abolished IIS-mediated longevity. Our study thus uncovered strikingly tissue-specific responses of cellular processes to lowered IIS acting in concert to ameliorate ageing.

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 Datum: 2017
 Publikationsstatus: Erschienen
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 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: Anderer: 28916541
DOI: 10.15252/msb.20177663
ISSN: 1744-4292 (Electronic)1744-4292 (Linking)
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Titel: Mol Syst Biol
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 13 (9) Artikelnummer: - Start- / Endseite: 939 Identifikator: -