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  Pattern formation by curvature-inducing proteins on spherical membranes

Agudo-Canalejo, J., & Golestanian, R. (2017). Pattern formation by curvature-inducing proteins on spherical membranes. New Journal of Physics, 19: 125013. doi:10.1088/1367-2630/aa983c.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-7467-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-7468-8
Genre: Journal Article

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Agudo-Canalejo, J., Author
Golestanian, Ramin1, Author              
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1Department of Living Matter Physics, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society, ou_2570692              

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 Abstract: Spatial organisation is a hallmark of all living cells, and recreating it in model systems is a necessary step in the creation of synthetic cells. It is therefore of both fundamental and practical interest to better understand the basic mechanisms underlying spatial organisation in cells. In this work, we use a continuum model of membrane and protein dynamics to study the behaviour of curvature-inducing proteins on membranes of spherical shape, such as living cells or lipid vesicles. We show that the interplay between curvature energy, entropic forces, and the geometric constraints on the membrane can result in the formation of patterns of highly-curved/protein-rich and weakly-curved/protein-poor domains on the membrane. The spontaneous formation of such patterns can be triggered either by an increase in the average density of curvature-inducing proteins, or by a relaxation of the geometric constraints on the membrane imposed by the membrane tension or by the tethering of the membrane to a rigid cell wall or cortex. These parameters can also be tuned to select the size and number of the protein-rich domains that arise upon pattern formation. The very general mechanism presented here could be related to protein self-organisation in many biological processes, ranging from (proto)cell division to the formation of membrane rafts. © 2017 The Author(s). Published by IOP Publishing Ltd on behalf of Deutsche Physikalische Gesellschaft.

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Language(s): eng - English
 Dates: 2017-12
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1088/1367-2630/aa983c
BibTex Citekey: Agudo-Canalejo2017
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Title: New Journal of Physics
Source Genre: Journal
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Pages: 13 Volume / Issue: 19 Sequence Number: 125013 Start / End Page: - Identifier: -