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  Supramolecular structure in the membrane of Staphylococcus aureus

García-Lara, J., Weihs, F., Ma, X., Walker, L., Chaudhuri, R. R., Kasturiarachchi, J., et al. (2015). Supramolecular structure in the membrane of Staphylococcus aureus. Proceedings of the National Academy of Sciences of the United States of America, 112(51), 15725-15730. doi:10.1073/pnas.1509557112.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-707B-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-707C-6
Genre: Journal Article

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García-Lara, J., Author
Weihs, F., Author
Ma, X., Author
Walker, L., Author
Chaudhuri, R. R., Author
Kasturiarachchi, J., Author
Crossley, H., Author
Golestanian, Ramin1, Author              
Foster, S. J., Author
Affiliations:
1Department of Living Matter Physics, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society, ou_2570692              

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 Abstract: All life demands the temporal and spatial control of essential biological functions. In bacteria, the recent discovery of coordinating elements provides a framework to begin to explain cell growth and division. Here we present the discovery of a supramolecular structure in the membrane of the coccal bacterium Staphylococcus aureus, which leads to the formation of a largescale pattern across the entire cell body; this has been unveiled by studying the distribution of essential proteins involved in lipid metabolism (PlsY and CdsA). The organization is found to require MreD, which determines morphology in rod-shaped cells. The distribution of protein complexes can be explained as a spontaneous pattern formation arising from the competition between the energy cost of bending that they impose on the membrane, their entropy of mixing, and the geometric constraints in the system. Our results provide evidence for the existence of a self-organized and nonpercolating molecular scaffold involving MreD as an organizer for optimal cell function and growth based on the intrinsic self-assembling properties of biological molecules.

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Language(s): eng - English
 Dates: 2015-12-072015-12-22
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1073/pnas.1509557112
BibTex Citekey: Garcia-Lara2015
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Title: Proceedings of the National Academy of Sciences of the United States of America
Source Genre: Journal
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Pages: - Volume / Issue: 112 (51) Sequence Number: - Start / End Page: 15725 - 15730 Identifier: -