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  Against the rules: pressure induced transition from high to reduced order

Neuhaus, F., Mueller, D., Tanasescu, R., Stefaniu, C., Zaffalon, P.-L., Balog, S., et al. (2018). Against the rules: pressure induced transition from high to reduced order. Soft Matter, 14(19), 3978-3986. doi:10.1039/C8SM00212F.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-6173-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-6174-F
Genre: Journal Article

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 Creators:
Neuhaus, Frederik, Author
Mueller, Dennis, Author
Tanasescu, Radu, Author
Stefaniu, Cristina1, Author              
Zaffalon, Pierre-Leonard, Author
Balog, Sandor, Author
Ishikawa, Takashi, Author
Reiter, Renate, Author
Brezesinski, Gerald2, Author              
Zumbuehl, Andreas, Author
Affiliations:
1Emanuel Schneck, Biomaterialien, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_2074300              
2Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863284              

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 Abstract: Envisioning the next generation of drug delivery nanocontainers requires more in-depth information on the fundamental physical forces at play in bilayer membranes. In order to achieve this, we combine chemical synthesis with physical-chemical analytical methods and probe the relationship between a molecular structure and its biophysical properties. With the aim of increasing the number of hydrogen bond donors compared to natural phospholipids, a phospholipid compound bearing urea moieties has been synthesized. The new molecules form interdigitated bilayers in aqueous dispersions and self-assemble at soft interfaces in thin layers with distinctive structural order. At lower temperatures, endothermic and exothermic transitions are observed during compression. The LC1 phase is dominated by an intermolecular hydrogen bond network of the urea moieties leading to a very high chain tilt of 52[degree]. During compression and at higher temperatures, presumably this hydrogen bond network is broken allowing a much lower chain tilt of 35[degree]. The extremely different monolayer thicknesses violate the two-dimensional Clausius-Clapeyron equation.

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 Dates: 2018
 Publication Status: Published in print
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 Identifiers: DOI: 10.1039/C8SM00212F
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Title: Soft Matter
  Abbreviation : Soft Matter
Source Genre: Journal
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Publ. Info: Cambridge, UK : Royal Society of Chemistry
Pages: - Volume / Issue: 14 (19) Sequence Number: - Start / End Page: 3978 - 3986 Identifier: ISSN: 1744-683X