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  Spinal and supraspinal mechanisms of placebo analgesia

Eippert, F., & Büchel, C. (2013). Spinal and supraspinal mechanisms of placebo analgesia. In L. Colloca, M. A. Flaten, & K. Meissner (Eds.), Placebo and Pain: From Bench to Bedside (pp. 53-71). Amsterdam: Academic Press. doi:10.1016/B978-0-12-397928-5.00007-6.

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 Creators:
Eippert, Falk1, Author           
Büchel, Christian2, Author
Affiliations:
1External Organizations, ou_persistent22              
2Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, ou_persistent22              

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Free keywords: placebo analgesia; pain; functional magnetic resonance imaging; human; descending pain control; spinal cord; brainstem; opioid; naloxone; periaqueductal gray
 Abstract: Placebo analgesia is an illustrative example of the impact that psychological factors can have on the experience of pain. While this form of pain modulation is mediated by multiple neurobiological mechanisms, one influential explanation posits that a descending pain control system contributes to placebo effects in pain. Here, we first give an overview of descending pain control as established in animal studies, focusing on an opioid-dependent system that includes the periaqueductal gray (PAG) and rostral ventromedial medulla (RVM) as core regions and controls nociceptive processing already at the level of the spinal cord. We then review functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) studies that provide evidence for an involvement of this system in placebo analgesia. Finally, we have a look at the role of the spinal cord in placebo analgesia, focusing on spinal fMRI studies.

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Language(s): eng - English
 Dates: 2013-09-062013
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/B978-0-12-397928-5.00007-6
ISBN: 978-0-12-397928-5
 Degree: -

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Title: Placebo and Pain: From Bench to Bedside
Source Genre: Book
 Creator(s):
Colloca, Luana1, Editor
Flaten, Magne Arve1, Editor
Meissner, Karin1, Editor
Affiliations:
1 External Organizations, ou_persistent22            
Publ. Info: Amsterdam : Academic Press
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 53 - 71 Identifier: -