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  Using the Mus musculus hybrid zone to assess covariation and genetic architecture of limb bone lengths

Skrabar, N., Turner, L. M., Pallares, L. F., Harr, B., & Tautz, D. (2018). Using the Mus musculus hybrid zone to assess covariation and genetic architecture of limb bone lengths. Molecular Ecology Resources, 18(4), 908-921. doi:10.1111/1755-0998.12776.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-6C92-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-F48D-B
Genre: Journal Article

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 Creators:
Skrabar, Neva1, Author              
Turner, Leslie M.1, Author              
Pallares, Luisa F.1, Author              
Harr, Bettina1, Author              
Tautz, Diethard1, Author              
Affiliations:
1Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445635              

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Free keywords: ecological genetics; hybrid zone; limbs; mapping; quantitative genetics
 Abstract: Two subspecies of the house mouse, Mus musculus domesticus and Mus musculus musculus, meet in a narrow contact zone across Europe. Mice in the hybrid zone are highly admixed, representing the full range of mixed ancestry from the two subspecies. Given the distinct morphologies of these subspecies, these natural hybrids can be used for genomewide association mapping at sufficiently high resolution to directly infer candidate genes. We focus here on limb bone length differences, which is of special interest for understanding the evolution of developmentally correlated traits. We used 172 first-generation descendants of wild-caught mice from the hybrid zone to measure the length of stylopod (humerus/femur), zeugopod (ulna/tibia) and autopod (metacarpal/metatarsal) elements in skeletal CT scans. We find phenotypic covariation between limb elements in the hybrids similar to patterns previously described in Mus musculus domesticus inbred strains, suggesting that the hybrid genotypes do not influence the covariation pattern in a major way. Mapping was performed using 143,592 SNPs and identified several genomic regions associated with length differences in each bone. Bone length was found to be highly polygenic. None of the candidate regions include the canonical genes known to control embryonic limb development. Instead, we are able to identify candidate genes with known roles in osteoblast differentiation and bone structure determination, as well as recently evolved genes of, as yet, unknown function. © 2018 John Wiley Sons Ltd.

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Language(s): eng - English
 Dates: 2018-02-202017-10-042018-02-262018-03-092018-07
 Publication Status: Published in print
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 Identifiers: DOI: 10.1111/1755-0998.12776
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Title: Molecular Ecology Resources
Source Genre: Journal
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Publ. Info: Oxford [u.a.] : Wiley-Blackwell
Pages: - Volume / Issue: 18 (4) Sequence Number: - Start / End Page: 908 - 921 Identifier: ISSN: 1755-0998
CoNE: https://pure.mpg.de/cone/journals/resource/1755-0998