English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Long-term heavy ketamine use is associated with spatial memory impairment and altered hippocampal activation

Morgan, C. J. A., Dodds, C. M., Furby, H., Pepper, F., Fam, J., Freeman, T. P., et al. (2014). Long-term heavy ketamine use is associated with spatial memory impairment and altered hippocampal activation. Frontiers in Psychiatry, 5: 149. doi:10.3389/fpsyt.2014.00149.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0001-709D-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-14B8-7
Genre: Journal Article

Files

show Files
hide Files
:
Morgan_2014.pdf (Publisher version), 2MB
Name:
Morgan_2014.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Morgan, Celia J. A.1, 2, Author
Dodds, Chris M.1, Author
Furby, Hannah3, Author
Pepper, Fiona4, Author
Fam, Johnson5, Author
Freeman, Tom P.2, Author
Hughes, Emer5, Author
Doeller, Christian F.6, Author              
King, John2, Author
Howes, Oliver5, Author
Stone, James M.4, 5, Author
Affiliations:
1Centre for Clinical Psychopharmacology, University of Exeter, United Kingdom, ou_persistent22              
2Clinical Psychopharmacology Unit, University College London, United Kingdom, ou_persistent22              
3Neuroimaging Sciences, Cardiff University, United Kingdom, ou_persistent22              
4Institute of Psychiatry, Kings College London, United Kingdom, ou_persistent22              
5Department of Experimental Medicine, Imperial College London, United Kingdom, ou_persistent22              
6Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands, ou_persistent22              

Content

show
hide
Free keywords: NMDA receptor; drug abuse; hippocampus; ketamine; memory; spatial memory
 Abstract: Ketamine, a non-competitive N-methyl-d-aspartate receptor antagonist, is rising in popularity as a drug of abuse. Preliminary evidence suggests that chronic, heavy ketamine use may have profound effects on spatial memory but the mechanism of these deficits is as yet unclear. This study aimed to examine the neural mechanism by which heavy ketamine use impairs spatial memory processing. In a sample of 11 frequent ketamine users and 15 poly-drug controls, matched for IQ, age, years in education. We used fMRI utilizing an ROI approach to examine the neural activity of three regions known to support successful navigation; the hippocampus, parahippocampal gyrus, and the caudate nucleus during a virtual reality task of spatial memory. Frequent ketamine users displayed spatial memory deficits, accompanied by and related to, reduced activation in both the right hippocampus and left parahippocampal gyrus during navigation from memory, and in the left caudate during memory updating, compared to controls. Ketamine users also exhibited schizotypal and dissociative symptoms that were related to hippocampal activation. Impairments in spatial memory observed in ketamine users are related to changes in medial temporal lobe activation. Disrupted medial temporal lobe function may be a consequence of chronic ketamine abuse and may relate to schizophrenia-like symptomatology observed in ketamine users.

Details

show
hide
Language(s): eng - English
 Dates: 2014-09-012014-10-122014-12-04
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.3389/fpsyt.2014.00149
PMID: 25538631
PMC: 4255515
Other: eCollection 2014
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Frontiers in Psychiatry
  Abbreviation : Front Psychiatry
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 5 Sequence Number: 149 Start / End Page: - Identifier: Other: 1664-0640
CoNE: https://pure.mpg.de/cone/journals/resource/16640640