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  Chapter Ten - A Protocol for Large-Scale Proteomic Analysis of Microdissected Formalin Fixed and Paraffin Embedded Tissue

Ostasiewicz, P., & Wisniewski, J. R. (2017). Chapter Ten - A Protocol for Large-Scale Proteomic Analysis of Microdissected Formalin Fixed and Paraffin Embedded Tissue. In A. K. Shukla (Ed.), Proteomics in Biology, Part A (pp. 159-176). Cambridge: Academic Press. doi:10.1016/bs.mie.2016.09.017.

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 Creators:
Ostasiewicz, P.1, Author
Wisniewski, J. R.2, Author              
Affiliations:
1external, ou_persistent22              
2Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565159              

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Free keywords: MASS-SPECTROMETRY; PROTEIN EXTRACTION; BREAST-CANCER; TUMOR-MARKERS; IDENTIFICATION; SHOTGUN; SAMPLES; BIOMARKERS; PROSTATE; FFPEBiochemistry & Molecular Biology;
 Abstract: Extensive use of biomarkers in diagnostic and therapeutic procedures is probably the hallmark of future medicine. Biomarkers can be of different chemical nature-most frequently DNA, RNA, and proteins are considered as molecules of interest. As the most rational approach appears analysis of proteins, because these are the "effector" molecules directly involved for cell homeostasis. There is no commonly accepted standard procedure in proteomic-based biomarker search. In this chapter, we described a protocol for proteomic analysis of formalin-fixed and paraffin-embedded tissue, which has been proven to be highly effective for proteomics-based biomarker discovery.

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Language(s): eng - English
 Dates: 2016-12-012017
 Publication Status: Published in print
 Pages: 18
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Degree: -

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Title: Proteomics in Biology, Part A
  Alternative Title : Methods Enzymol.
  Alternative Title : METHOD ENZYMOL
Source Genre: Book
 Creator(s):
Shukla, Arun K., Editor
Affiliations:
-
Publ. Info: Cambridge : Academic Press
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 159 - 176 Identifier: ISSN: 0076-6879
ISBN: 978-0-12-810534-4; 978-0-12-809742-7

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Title: Methods in Enzymology
  Alternative Title : METHOD ENZYMOL
  Alternative Title : Methods Enzymol.
Source Genre: Series
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 585 Sequence Number: - Start / End Page: - Identifier: ISSN: 0076-6879