Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

EndNote (UTF-8)
 
DownloadE-Mail
  Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group

Schmaal, L., Hibar, D. P., Sämann, P. G., Hall, G. B., Baune, B. T., Jahanshad, N., et al. (2017). Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group. MOLECULAR PSYCHIATRY, 22(6), 900-909. doi:10.1038/mp.2016.60.

Item is

Basisdaten

ausblenden:
Genre: Zeitschriftenartikel

Dateien

ausblenden: Dateien
:
mp201660.pdf (Verlagsversion), 283KB
Name:
mp201660.pdf
Beschreibung:
-
OA-Status:
Sichtbarkeit:
Öffentlich
MIME-Typ / Prüfsumme:
application/pdf / [MD5]
Technische Metadaten:
Copyright Datum:
-
Copyright Info:
-

Externe Referenzen

einblenden:

Urheber

ausblenden:
 Urheber:
Schmaal, L.1, Autor
Hibar, D. P.1, Autor
Sämann, P. G.2, Autor           
Hall, G. B.1, Autor
Baune, B. T.1, Autor
Jahanshad, N.1, Autor
Cheung, J. W.1, Autor
van Erp, T. G. M.1, Autor
Bos, D.1, Autor
Ikram, M. A.1, Autor
Vernooij, M. W.1, Autor
Niessen, W. J.1, Autor
Tiemeier, H.1, Autor
Hofman, A.1, Autor
Wittfeld, K.1, Autor
Grabe, H. J.1, Autor
Janowitz, D.1, Autor
Buelow, R.1, Autor
Selonke, M.1, Autor
Voelzke, H.1, Autor
mehr..
Affiliations:
1external, ou_persistent22              
2Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

Inhalt

ausblenden:
Schlagwörter: VOXEL-BASED MORPHOMETRY; ANTERIOR CINGULATE CORTEX; GRAY-MATTER VOLUME; SURFACE-AREA; MOOD DISORDERS; HEALTHY-CHILDREN; DRUG-NAIVE; LIFE-SPAN; THICKNESS; METAANALYSISBiochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry;
 Zusammenfassung: The neuro-anatomical substrates of major depressive disorder (MDD) are still not well understood, despite many neuroimaging studies over the past few decades. Here we present the largest ever worldwide study by the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Major Depressive Disorder Working Group on cortical structural alterations in MDD. Structural T1-weighted brain magnetic resonance imaging (MRI) scans from 2148 MDD patients and 7957 healthy controls were analysed with harmonized protocols at 20 sites around the world. To detect consistent effects of MDD and its modulators on cortical thickness and surface area estimates derived from MRI, statistical effects from sites were meta-analysed separately for adults and adolescents. Adults with MDD had thinner cortical gray matter than controls in the orbitofrontal cortex (OFC), anterior and posterior cingulate, insula and temporal lobes (Cohen's d effect sizes: -0.10 to -0.14). These effects were most pronounced in first episode and adult-onset patients (>21 years). Compared to matched controls, adolescents with MDD had lower total surface area (but no differences in cortical thickness) and regional reductions in frontal regions (medial OFC and superior frontal gyrus) and primary and higher-order visual, somatosensory and motor areas (d: -0.26 to -0.57). The strongest effects were found in recurrent adolescent patients. This highly powered global effort to identify consistent brain abnormalities showed widespread cortical alterations in MDD patients as compared to controls and suggests that MDD may impact brain structure in a highly dynamic way, with different patterns of alterations at different stages of life.

Details

ausblenden:
Sprache(n): eng - English
 Datum: 2017
 Publikationsstatus: Erschienen
 Seiten: 10
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: ISI: 000401702800013
DOI: 10.1038/mp.2016.60
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

ausblenden:
Projektname : -
Grant ID : 01GS0481
Förderprogramm : National Genome Research Network (NGFN)
Förderorganisation : Federal Ministry of Education and Research (BMBF)
Projektname : -
Grant ID : 01ZZ9603
Förderprogramm : -
Förderorganisation : German Federal Ministry of Education and Research (BMBF)
Projektname : -
Grant ID : 01ZZ0103
Förderprogramm : -
Förderorganisation : German Federal Ministry of Education and Research (BMBF)
Projektname : -
Grant ID : 01ZZ0403
Förderprogramm : -
Förderorganisation : German Federal Ministry of Education and Research (BMBF)
Projektname : -
Grant ID : GR1912/5-1
Förderprogramm : -
Förderorganisation : German Research Foundation

Quelle 1

ausblenden:
Titel: MOLECULAR PSYCHIATRY
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: NATURE PUBLISHING GROUP
Seiten: - Band / Heft: 22 (6) Artikelnummer: - Start- / Endseite: 900 - 909 Identifikator: ISSN: 1359-4184