非表示:
キーワード:
CORTICOTROPIN-RELEASING-FACTOR; VENTRAL TEGMENTAL AREA; C57BL/6J MICE;
CENTRAL AMYGDALA; BINGE DRINKING; REGULATES FOOD; CRF NEURONS;
BRAIN-STEM; RAT-BRAIN; ADDICTIONPsychiatry;
要旨:
Midbrain neurons of the centrally projecting Edinger-Westphal nucleus (EWcp) are activated by alcohol, and enriched with stress-responsive neuropeptide modulators (including the paralog of corticotropin-releasing factor, urocortin-1). Evidence suggests that EWcp neurons promote behavioral processes for alcohol-seeking and consumption, but a definitive role for these cells remains elusive. Here we combined targeted viral manipulations and gene array profiling of EWcp neurons with mass behavioral phenotyping in C57BL/6 J mice to directly define the links between EWcp-specific urocortin-1 expression and voluntary binge alcohol intake, demonstrating a specific importance for EWcp urocortin-1 activity in escalation of alcohol intake.
