English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Methylene Blue (Tetramethylthionine Chloride) Influences the Mobility of Adult Neural Stem Cells: A Potentially Novel Therapeutic Mechanism of a Therapeutic Approach in the Treatment of Alzheimer's Disease

van der Ven, A. T., Pape, J. C., Herman, D., Schloesser, R., Genius, J., Fischer, N., et al. (2017). Methylene Blue (Tetramethylthionine Chloride) Influences the Mobility of Adult Neural Stem Cells: A Potentially Novel Therapeutic Mechanism of a Therapeutic Approach in the Treatment of Alzheimer's Disease. JOURNAL OF ALZHEIMERS DISEASE, 57(2), 531-540. doi:10.3233/JAD-160755.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0001-BE17-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-BE18-F
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
van der Ven, Amelie T.1, Author
Pape, Julius C.2, Author              
Herman, Dirk1, Author
Schloesser, Robert1, Author
Genius, Just1, Author
Fischer, Nadine1, Author
Moessner, Rainald1, Author
Scherbaum, Norbert1, Author
Wiltfang, Jens1, Author
Rujescu, Dan1, Author
Benninghoff, Jens1, Author
Affiliations:
1external, ou_persistent22              
2Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society, ou_2035295              

Content

show
hide
Free keywords: AGGREGATION INHIBITOR THERAPY; CENTRAL-NERVOUS-SYSTEM; NEUROTROPHIC FACTOR; TAU-AGGREGATION; A-BETA; SUBVENTRICULAR ZONE; DENTATE GYRUS; BRAIN; NEUROGENESIS; MICENeurosciences & Neurology; Adult stem cells; Alzheimer's disease; methylene blue; neural plasticity;
 Abstract: An interest in neurogenesis in the adult human brain as a relevant and targetable process has emerged as a potential treatment option for Alzheimer's disease and other neurodegenerative conditions. The aim of this study was to investigate the effects of tetramethylthionine chloride (methylene blue, MB) on properties of adult murine neural stem cells. Based on recent clinical studies, MB has increasingly been discussed as a potential treatment for Alzheimer's disease. While no differences in the proliferative capacity were identified, a general potential of MB in modulating the migratory capacity of adult neural stem cells was indicated in a cell mobility assay. To our knowledge, this is the first time that MB could be associated with neural mobility. The results of this study add insight to the spectrum of features of MB within the central nervous system and may be helpful for understanding the molecular mechanisms underlying a potential therapeutic effect of MB.

Details

show
hide
Language(s): eng - English
 Dates: 2017
 Publication Status: Published in print
 Pages: 10
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: ISI: 000398725100017
DOI: 10.3233/JAD-160755
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: JOURNAL OF ALZHEIMERS DISEASE
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: IOS PRESS
Pages: - Volume / Issue: 57 (2) Sequence Number: - Start / End Page: 531 - 540 Identifier: ISSN: 1387-2877