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  Differential hippocampal and prefrontal-striatal contributions to instance-based and rule-based learning

Doeller, C. F., Opitz, B., Krick, C. M., Mecklinger, A., & Reith, W. (2006). Differential hippocampal and prefrontal-striatal contributions to instance-based and rule-based learning. NeuroImage, 31(4), 1802-1816. doi:10.1016/j.neuroimage.2006.02.006.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-7113-A Version Permalink: http://hdl.handle.net/21.11116/0000-0002-94C7-6
Genre: Journal Article

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 Creators:
Doeller, Christian F.1, 2, 3, Author              
Opitz, Bertram3, Author
Krick, Christoph M.4, Author
Mecklinger, Axel3, Author
Reith, Wolfgang4, Author
Affiliations:
1Institute of Cognitive Neuroscience, University College London, United Kingdom, ou_persistent22              
2Department of Anatomy and Developmental Biology, University College London, United Kingdom, ou_persistent22              
3Experimental Neuropsychology Unit, Department of Psychology, Saarland University, Saarbrücken, Germany, ou_persistent22              
4Department of Neuroradiology, Saarland University Hospital, Homburg, Germany, ou_persistent22              

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Free keywords: fMRI; Instance-based learning; Prefrontal cortex; Rule-based learning; Striatum
 Abstract: It is a topic of current interest whether learning in humans relies on the acquisition of abstract rule knowledge (rule-based learning) or whether it depends on superficial item-specific information (instance-based learning). Here, we identified brain regions that mediate either of the two learning mechanisms by combining fMRI with an experimental protocol shown to be able to dissociate both learning mechanisms. Subjects had to learn object-position conjunctions in several trials and blocks. In a learning condition, either objects (Experiment 1) or positions (Experiment 2) were held constant within-blocks. In contrast to a control condition in which object–position conjunctions were trial-unique, a performance increase within and across-blocks was observed in the learning condition of both experiments. We hypothesized that within-block learning mainly relies on instance-based processes, whereas across-block learning might depend on rule-based mechanisms. A within-block parametric fMRI analysis revealed a learning-related increase of lateral prefrontal and striatal activity and a learning-related decrease of hippocampal activity in both experiments. By contrast, across-block learning was associated with an activation modulation in distinct prefrontal-striatal brain regions, but not in the hippocampus. These data indicate that hippocampal and prefrontal-striatal brain regions differentially contribute to instance-based and rule-based learning.

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Language(s): eng - English
 Dates: 2006-01-272005-06-022006-02-032006-03-242006-07-15
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2006.02.006
PMID: 16563803
 Degree: -

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Title: NeuroImage
Source Genre: Journal
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Affiliations:
Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 31 (4) Sequence Number: - Start / End Page: 1802 - 1816 Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166