English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Prefrontal-hippocampal dynamics involved in learning regularities across episodes

Doeller, C. F., Opitz, B., Krick, C. M., Mecklinger, A., & Reith, W. (2005). Prefrontal-hippocampal dynamics involved in learning regularities across episodes. Cerebral Cortex, 15(8), 1123-1133. doi:10.1093/cercor/bhh211.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0001-7111-C Version Permalink: http://hdl.handle.net/21.11116/0000-0002-94C3-A
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Doeller, Christian F.1, Author              
Opitz , Bertram1, Author
Krick , Christoph M.2, Author
Mecklinger , Axel1, Author
Reith , Wolfgang2, Author
Affiliations:
1Experimental Neuropsychology Unit, Department of Psychology, Saarland University, Saarbrücken, Germany, ou_persistent22              
2Department of Neuroradiology, Saarland University Hospital, Homburg, Germany, ou_persistent22              

Content

show
hide
Free keywords: fMRI; hippocampus; learning; prefrontal cortex; ventral striatum
 Abstract: Using functional magnetic resonance imaging, the neural correlates of context-specific memories and invariant memories about regularities across episodes were investigated. Volunteers had to learn conjunctions between objects and positions. In an invariant learning condition, positions were held constant, enabling subjects to learn regularities across trials. By contrast, in a context-specific condition object–position conjunctions were trial unique. Performance increase in the invariant learning condition was paralleled by a learning-related increase of inferior frontal gyrus activation and ventral striatal activation and a decrease of hippocampus activation. Conversely, in the context-specific condition hippocampal activation was constant across trials. We argue that the learning-related hippocampal activation pattern might be due to reduced relational binding requirements once regularities are extracted. Furthermore, we propose that the learning-related prefrontal modulation reflects the requirement to extract and maintain regularities across trials and the adjustment of object–position conjunctions on the basis of the extracted knowledge. Finally, our data suggest that the ventral striatum encodes the increased predictability of spatial features as a function of learning. Taken together, these results indicate a transition of the relative roles of distinct brain regions during learning regularities across multiple episodes: regularity learning is characterized by a shift from a hippocampal to a prefrontal–striatal brain system.

Details

show
hide
Language(s): eng - English
 Dates: 2004-11-242005-08-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1093/cercor/bhh211
PMID: 15563722
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Cerebral Cortex
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York, NY : Oxford University Press
Pages: - Volume / Issue: 15 (8) Sequence Number: - Start / End Page: 1123 - 1133 Identifier: ISSN: 1047-3211
CoNE: https://pure.mpg.de/cone/journals/resource/954925592440