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  Application of the distance-based F test in an mGWAS investigating β diversity of intestinal microbiota identifies variants in SLC9A8 (NHE8) and 3 other loci

Ruhlemann, M. C., Degenhardta, F., Thingholm, L. B., Wang, J., Skieceviciene, J., Rausch, P., et al. (2018). Application of the distance-based F test in an mGWAS investigating β diversity of intestinal microbiota identifies variants in SLC9A8 (NHE8) and 3 other loci. Gut Microbes, 9(1), 68-75. doi:10.1080/19490976.2017.1356979.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-704B-D Version Permalink: http://hdl.handle.net/21.11116/0000-0003-E3CF-4
Genre: Journal Article

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Application of the distance based F test in an mGWAS investigating diversity of intestinal microbiota identifies variants in SLC9A8 NHE8 and 3 other.pdf (Publisher version), 2MB
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Application of the distance based F test in an mGWAS investigating diversity of intestinal microbiota identifies variants in SLC9A8 NHE8 and 3 other.pdf
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 Creators:
Ruhlemann, Malte C., Author
Degenhardta, Frauke, Author
Thingholm, Louise B., Author
Wang, Jun1, Author              
Skieceviciene, Jurgita, Author
Rausch, Philipp1, Author              
Hov, Johannes R., Author
Lieb, Wolfgang, Author
Karlsen, Tom H., Author
Laudes, Matthias, Author
Baines, John F.1, Author              
Heinsen, Femke-Anouska, Author
Franke, Andre, Author
Affiliations:
1Guest Group Evolutionary Genomics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445638              

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Free keywords: β diversity; GWAS; human gut microbiota; immunity; IBD
 Abstract: Factors shaping the human intestinal microbiota range from environmental influences, like smoking and exercise, over dietary patterns and disease to the host's genetic variation. Recently, we could show in a microbiome genome-wide association study (mGWAS) targeting genetic variation influencing the β diversity of gut microbial communities, that approximately 10% of the overall gut microbiome variation can be explained by host genetics. Here, we report on the application of a new method for genotype-β-diversity association testing, the distance-based F (DBF) test. With this we identified 4 loci with genome-wide significant associations, harboring the genes CBEP4, SLC9A8, TNFSF4, and SP140, respectively. Our findings highlight the utility of the high-performance DBF test in β diversity GWAS and emphasize the important role of host genetics and immunity in shaping the human intestinal microbiota.

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Language(s): eng - English
 Dates: 2017-03-312017-07-112017-08-282018
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1080/19490976.2017.1356979
 Degree: -

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Project name : Origin and Function of Metaorganisms
Grant ID : -
Funding program : -
Funding organization : German Research Foundation
Project name : CP3 in SysINFLAME
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Funding program : -
Funding organization : German Federal Ministry of Education and Research (BMBF)
Project name : Inflammation at Interfaces
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Funding program : -
Funding organization : DFG Excellence Cluster 306

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Title: Gut Microbes
Source Genre: Journal
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Publ. Info: Taylor & Francis
Pages: - Volume / Issue: 9 (1) Sequence Number: - Start / End Page: 68 - 75 Identifier: Other: http://www.sherpa.ac.uk/romeo/issn/1949-0976/
Other: http://www.tandfonline.com/loi/kgmi20
Other: http://ezb.uni-regensburg.de/searchres.phtml?bibid=MPG&colors=7&lang=de&jq_type1=QS&jq_term1=gut+microbes
Other: 1949-0984
Other: https://zdb-katalog.de/list.xhtml?t=gut+microbes
CoNE: /journals/resource/1949-0976