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  Analysis of 3800-year-old Yersinia pestis genomes suggests Bronze Age origin for bubonic plague

Spyrou, M. A., Tukhbatova, R. I., Wang, C.-C., Andrades Valtueña, A., Lankapalli, A. K., Kondrashin, V. V., et al. (2018). Analysis of 3800-year-old Yersinia pestis genomes suggests Bronze Age origin for bubonic plague. Nature Communications, 9: 2234. doi:10.1038/s41467-018-04550-9.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-7199-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-9431-E
Genre: Journal Article

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 Creators:
Spyrou, Maria A.1, Author              
Tukhbatova, Rezeda I., Author
Wang, Chuan-Chao1, 2, Author              
Andrades Valtueña, Aida1, Author              
Lankapalli, Aditya Kumar1, Author              
Kondrashin, Vitaly V., Author
Tsybin, Victor A., Author
Khokhlov, Aleksandr, Author
Kühnert, Denise3, Author              
Herbig, Alexander1, Author              
Bos, Kirsten I.1, Author              
Krause, Johannes1, 4, Author              
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              
2Eurasia3angle, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2301699              
3tide, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2591691              
4MHAAM, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2541699              

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 Abstract: The origin of Yersinia pestis and the early stages of its evolution are fundamental subjects of investigation given its high virulence and mortality that resulted from past pandemics. Although the earliest evidence of Y. pestis infections in humans has been identified in Late Neolithic/Bronze Age Eurasia (LNBA 5000–3500y BP), these strains lack key genetic components required for flea adaptation, thus making their mode of transmission and disease presentation in humans unclear. Here, we reconstruct ancient Y. pestis genomes from individuals associated with the Late Bronze Age period (~3800 BP) in the Samara region of modern-day Russia. We show clear distinctions between our new strains and the LNBA lineage, and suggest that the full ability for flea-mediated transmission causing bubonic plague evolved more than 1000 years earlier than previously suggested. Finally, we propose that several Y. pestis lineages were established during the Bronze Age, some of which persist to the present day.

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Language(s): eng - English
 Dates: 2018-06-08
 Publication Status: Published online
 Pages: 10
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: Other: shh1006
DOI: 10.1038/s41467-018-04550-9
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Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: 2234 Volume / Issue: 9 Sequence Number: 2234 Start / End Page: - Identifier: ISSN: 2041-1723
CoNE: /journals/resource/2041-1723