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  Quantitative susceptibility mapping of amyloid-β aggregates in Alzheimer’s disease with 7T MR

Tiepolt, S., Schäfer, A., Rullmann, M., Roggenhofer, E., Netherlands Brain Bank, Gertz, H.-J., et al. (2018). Quantitative susceptibility mapping of amyloid-β aggregates in Alzheimer’s disease with 7T MR. Journal of Alzheimer's Disease, 64(2), 393-404. doi:10.3233/JAD-180118.

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Tiepolt, Solveig1, Author
Schäfer, Andreas2, 3, Author              
Rullmann, Michael1, 4, Author              
Roggenhofer, Elisabeth4, 5, Author              
Netherlands Brain Bank, Author              
Gertz, Hermann-Josef6, Author
Schroeter, Matthias L.4, 7, Author              
Patt, Marianne1, Author
Bazin, Pierre-Louis2, Author              
Jochimsen, Thies H.1, Author
Turner, Robert8, Author              
Sabri, Osama1, Author
Barthel, Henryk1, Author
1Department of Nuclear Medicine, University of Leipzig, Germany, ou_persistent22              
2Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
3Siemens Sector Healthcare, Erlangen, Germany, ou_persistent22              
4Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
5Laboratoire de Recherche en Neuroimagerie (LREN), Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
6Department of Psychiatry, University of Leipzig, Germany, ou_persistent22              
7Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
8Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634550              


Free keywords: Alzheimer’s disease; Amyloid; Iron accumulation; Quantitative susceptibility mapping; 7T MRI
 Abstract: PET imaging is an established technique to detect cerebral amyloid-β (Aβ) plaques in vivo. Some preclinical and postmortem data report an accumulation of redox-active iron near Aβ plaques. Quantitative susceptibility mapping (QSM) at high-field MRI enables iron deposits to be depicted with high spatial resolution. OBJECTIVE: Aim of this study was to examine whether iron and Aβ plaque accumulation is related and thus, whether 7T MRI might be an additive diagnostic tool to Aβ PET imaging. METHODS: Postmortem human Alzheimer's disease (AD) and healthy control (HC) frontal gray matter (GM) was imaged with 7T MRI which resulted in T1 maps and QSM. Aβ plaque load was determined by histopathology. In vivo, 10 Aβ PET-positive AD patients (74.1±6.0a) and 10 Aβ PET-negative HCs (67.1±4.4a) underwent 7T MR examination and QSM maps were analyzed. Severity of cognitive deficits was determined by MMSE. RESULTS: Postmortem, the susceptibility of Aβ plaque-containing GM were higher than those of Aβ plaque-free GM (0.011±0.002 versus - 0.008±0.003 ppm, p <  0.001). In vivo, only the bilateral globus pallidus showed significantly higher susceptibility in AD patients compared to HCs (right: 0.277±0.018 versus - 0.009±0.009 ppm; left: 0.293±0.014 versus - 0.007±0.012 ppm, p <  0.0001). The pallidal QSM values were negatively correlated with those of the MMSE (r = - 0.69, p = 0.001). CONCLUSION: The postmortem study revealed significant susceptibility differences between the Aβ plaque-containing and Aβ plaque-free GM, whereas in vivo only the QSM values of the globus pallidus differed significantly between AD and HC group. The pallidal QSM values correlated with the severity of cognitive deficits. These findings encourage efforts to optimize the 7T-QSM methodology.


Language(s): eng - English
 Dates: 2018-04-232018-06-192018
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.3233/JAD-180118
PMID: 29865069
 Degree: -



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Title: Journal of Alzheimer's Disease
  Abbreviation : J. Alzheimers Dis.
Source Genre: Journal
Publ. Info: Amsterdam : IOS Press
Pages: - Volume / Issue: 64 (2) Sequence Number: - Start / End Page: 393 - 404 Identifier: ISSN: 1387-2877
CoNE: https://pure.mpg.de/cone/journals/resource/1387-2877