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  Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

Davies, G., Lam, M., Harris, S. E., Trampush, J. W., Luciano, M., Hill, W. D., et al. (2018). Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. Nature Communications, 9: 2098. doi:10.1038/s41467-018-04362-x.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-780D-B Version Permalink: http://hdl.handle.net/21.11116/0000-0005-0F32-3
Genre: Journal Article

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Davies, Gail1, Author
Lam, Max1, Author
Harris, Sarah E.1, Author
Trampush, Joey W.1, Author
Luciano, Michelle1, Author
Hill, W. David1, Author
Hagenaars, Saskia P.1, Author
Ritchie, Stuart J.1, Author
Marioni, Riccardo E.1, Author
Fawns-Ritchie, Chloe1, Author
Liewald, David C. M.1, Author
Okely, Judith A.1, Author
Ahola-Olli, Ari V.1, Author
Barnes, Catriona L. K.1, Author
Bertram, Lars1, Author
Bis, Joshua C.1, Author
Burdick, Katherine E.1, Author
Christoforou, Andrea1, Author
DeRosse, Pamela1, Author
Djurovic, Srdjan1, Author
Espeseth, Thomas1, AuthorGiakoumaki, Stella1, AuthorGiddaluru, Sudheer1, AuthorGustavson, Daniel E.1, AuthorHayward, Caroline1, AuthorHofer, Edith1, AuthorIkram, M. Arfan1, AuthorKarlsson, Robert1, AuthorKnowles, Emma1, AuthorLahti, Jari1, AuthorLeber, Markus1, AuthorLi, Shuo1, AuthorMather, Karen A.1, AuthorMelle, Ingrid1, AuthorMorris, Derek1, AuthorOldmeadow, Christopher1, AuthorPalviainen, Teemu1, AuthorPayton, Antony1, AuthorPazoki, Raha1, AuthorPetrovic, Katja1, AuthorReynolds, Chandra A.1, AuthorSargurupremraj, Muralidharan1, AuthorScholz, Markus1, AuthorSmith, Jennifer A.1, AuthorSmith, Albert V.1, AuthorTerzikhan, Natalie1, AuthorThalamuthu, Anbupalam1, AuthorTrompet, Stella1, Authorvan der Lee, Sven J.1, AuthorWare, Erin B.1, AuthorWindham, B. Gwen1, AuthorWright, Margaret J.1, AuthorYang, Jingyun1, AuthorYu, Jin1, AuthorAmes, David1, AuthorAmin, Najaf1, AuthorAmouyel , Philippe1, AuthorAndreassen, Ole A.1, AuthorArmstrong, Nicola J.1, AuthorAssareh, Amelia A.1, AuthorAttia, John R.1, AuthorAttix, Deborah1, AuthorAvramopoulos, Dimitrios1, AuthorBennett, David A.1, AuthorBöhmer, Anne C.1, AuthorBoyle, Patricia A.1, AuthorBrodaty, Henry1, AuthorCampbell, Harry1, AuthorCannon, Tyrone D.1, AuthorCirulli, Elizabeth T.1, AuthorCongdon, Eliza1, AuthorConley, Emily Drabant1, AuthorCorley, Janie1, AuthorCox, Simon R.1, AuthorDale, Anders M.1, AuthorDehghan, Abbas1, AuthorDick, Danielle1, AuthorDickinson, Dwight1, AuthorEriksson, Johan G.1, AuthorEvangelou, Evangelos1, AuthorFaul, Jessica D.1, AuthorFord, Ian1, AuthorFreimer, Nelson A.1, AuthorGao, He1, AuthorGiegling, Ina1, AuthorGillespie, Nathan A.1, AuthorGordon, Scott D.1, AuthorGottesman, Rebecca F.1, AuthorGriswold, Michael E.1, AuthorGudnason, Vilmundur1, AuthorHarris, Tamara B.1, AuthorHartmann, Annette M.1, AuthorHatzimanolis, Alex1, AuthorHeiss, Gerardo1, AuthorHolliday, Elizabeth G.1, AuthorJoshi, Peter K.1, AuthorKähönen, Mika1, AuthorKardia, Sharon L. R.1, AuthorKarlsson, Ida1, AuthorKleineidam, Luca1, AuthorKnopman, David S.1, AuthorKochan, Nicole A.1, AuthorKonte, Bettina1, AuthorKwok, John B.1, AuthorLe Hellard, Stephanie1, AuthorLee, Teresa1, AuthorLehtimäki, Terho1, AuthorLiu, Tian1, AuthorLi, Shu-Chen1, AuthorKoini, Marisa1, AuthorLondon, Edythe1, AuthorLongstreth Jr, Will T.1, AuthorLopez, Oscar L.1, AuthorLoukola, Anu1, AuthorLuck, Tobias1, AuthorLundervold, Astri J.1, AuthorLundquist, Anders 1, AuthorLyytikäinen, Leo-Pekka1, AuthorMartin, Nicholas G.1, AuthorMontgomery, Grant W.1, AuthorMurray, Alison D.1, AuthorNeed, Anna C.1, AuthorNoordam, Raymond1, AuthorNyberg, Lars1, AuthorOllier, William1, AuthorPapenberg, Goran1, AuthorPattie, Alison1, AuthorPolasek, Ozren1, AuthorPoldrack, Russell A.1, AuthorPsaty, Bruce M.1, AuthorReppermund, Simone1, AuthorRiedel-Heller, Steffi G.1, AuthorRose, Richard J.1, AuthorRotter, Jerome I.1, AuthorRoussos, Panos1, AuthorRovio, Suvi P.1, AuthorSaba, Yasaman1, AuthorSabb, Fred W.1, AuthorSachdev, Perminder S.1, AuthorSatizabal, Claudia L.1, AuthorSchmid, Matthias1, AuthorScott, Rodney J.1, AuthorScult, Matthew A.1, AuthorSimino, Jeannette1, AuthorSlagboom, P. Eline1, AuthorSmyrnis, Nikolaos1, AuthorSoumaré, Aïcha1, AuthorStefanis, Nikos C.1, AuthorStott, David J.1, AuthorStraub, Richard E.1, AuthorSundet, Kjetil1, AuthorTaylor, Adele M.1, AuthorTaylor , Kent D. 1, AuthorTzoulaki, Ioanna1, AuthorTzourio, Christophe1, AuthorUitterlinden, André1, AuthorVitart, Veronique1, AuthorVoineskos, Aristotle N.1, AuthorKaprio, Jaakko1, AuthorWagner, Michael1, AuthorWagner, Holger1, AuthorWeinhold, Leonie1, AuthorWen, K. Hoyan1, AuthorWiden, Elisabeth1, AuthorYang, Qiong1, AuthorZhao, Wei1, AuthorAdams, Hieab H. H.1, AuthorArking, Dan E.1, AuthorBilder, Robert M.1, AuthorBitsios, Panos1, AuthorBoerwinkle, Eric1, AuthorChiba-Falek, Ornit1, AuthorCorvin, Aiden1, AuthorDe Jager, Philip L.1, AuthorDebette, Stéphanie1, AuthorDonohoe, Gary1, AuthorElliott, Paul1, AuthorFitzpatrick, Annette L.1, AuthorGill, Michael1, AuthorGlahn, David C.1, AuthorHägg, Sara1, AuthorHansell , Narelle K.1, AuthorHariri, Ahmad R.1, AuthorIkram, M. Kamran 1, AuthorJukema, J. Wouter1, AuthorVuoksimaa, Eero1, AuthorKeller, Matthew C.1, AuthorKremen, William S.1, AuthorLauner, Lenore1, AuthorLindenberger, Ulman1, AuthorPalotie, Aarno1, AuthorPedersen, Nancy L.1, AuthorPendleton, Neil1, AuthorPorteous, David J.1, AuthorRäikkönen, Katri1, AuthorRaitakari, Olli T.1, AuthorRamirez, Alfredo1, AuthorReinvang, Ivar1, AuthorRudan, Igor1, AuthorRujescu, Dan1, AuthorSchmidt, Reinhold1, AuthorSchmidt, Helena1, AuthorSchofield, Peter W.1, AuthorSchofield, Peter R.1, AuthorStarr, John M.1, AuthorSteen, Vidar M.1, AuthorTrollor, Julian N.1, AuthorTurner, Steven T.1, AuthorVan Duijn, Cornelia M.1, AuthorVillringer, Arno1, 2, Author              Weinberger, Daniel R.1, AuthorWeir, David R.1, AuthorWilson, James F.1, AuthorMalhotra, Anil1, AuthorMcIntosh, Andrew M.1, AuthorGale, Catharine R.1, AuthorSeshadri, Sudha1, AuthorMosley Jr, Thomas H.1, AuthorBressler, Jan1, AuthorLencz, Todd1, AuthorDeary, Ian J.1, Author more..
Affiliations:
1External Organizations, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

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 Abstract: General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16–102) and find 148 genome-wide significant independent loci (P < 5 × 10−8) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function is predicted in independent samples. We detect significant genetic overlap between general cognitive function, reaction time, and many health variables including eyesight, hypertension, and longevity. In conclusion we identify novel genetic loci and pathways contributing to the heritability of general cognitive function.

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Language(s): eng - English
 Dates: 2017-08-312018-04-232018-05-29
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1038/s41467-018-04362-x
PMID: 29844566
PMC: PMC5974083
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Grant ID : MR/K026992/1
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Funding organization : Medical Research Council (MRC)
Project name : -
Grant ID : R01 AG033193 ; U01 AG049505 ; U01 AG052409
Funding program : -
Funding organization : National Institute on Aging
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Funding organization : Biotechnology and Biological Sciences Research Council (BBSRC)

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Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 9 Sequence Number: 2098 Start / End Page: - Identifier: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723