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  What is the evidence that tau pathology spreads through prion-like propagation?

Mudher, A., Colin, M., Dujardin, S., Medina, M., Dewachter, I., Naini, S. M. A., Mandelkow, E.-M., Mandelkow, E., Buee, L., Goedert, M., & Brion, J.-P. (2017). What is the evidence that tau pathology spreads through prion-like propagation? Acta Neuropathologica Communications, 5(1):. doi:10.1186/s40478-017-0488-7.

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アイテムのパーマリンク: https://hdl.handle.net/21.11116/0000-0001-78C8-7 版のパーマリンク: https://hdl.handle.net/21.11116/0000-0007-50F1-E
資料種別: 学術論文

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s40478-017-0488-7.pdf (出版社版), 2MB
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https://hdl.handle.net/21.11116/0000-0001-78CA-5
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s40478-017-0488-7.pdf
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 作成者:
Mudher, Amrit1, 著者
Colin, Morvane1, 著者
Dujardin, Simon1, 著者
Medina, Miguel1, 著者
Dewachter, Ilse1, 著者
Naini, Seyedeh Maryam Alavi1, 著者
Mandelkow, Eva-Maria1, 2, 著者
Mandelkow, Eckhard1, 2, 著者
Buee, Luc1, 著者
Goedert, Michel1, 著者
Brion, Jean-Pierre1, 著者
所属:
1external, ou_persistent22              
2Neuronal Cytoskeleton and Alzheimer's Disease, Cooperations, Center of Advanced European Studies and Research (caesar), Max Planck Society, Ludwig-Erhard-Allee 2, 53175 Bonn, DE, ou_2173677              

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 要旨: Emerging experimental evidence suggests that the spread of tau pathology in the brain in Tauopathies reflects the propagation of abnormal tau species along neuroanatomically connected brain areas. This propagation could occur through a "prion-like" mechanism involving transfer of abnormal tau seeds from a "donor cell" to a "recipient cell" and recruitment of normal tau in the latter to generate new tau seeds. This review critically appraises the evidence that the spread of tau pathology occurs via such a "prion-like" mechanism and proposes a number of recommendations for directing future research. Recommendations for definitions of frequently used terms in the tau field are presented in an attempt to clarify and standardize interpretation of research findings. Molecular and cellular factors affecting tau aggregation are briefly reviewed, as are potential contributions of physiological and pathological post-translational modifications of tau. Additionally, the experimental evidence for tau seeding and "prion-like" propagation of tau aggregation that has emerged from cellular assays and in vivo models is discussed. Propagation of tau pathology using "prion-like" mechanisms is expected to incorporate several steps including cellular uptake, templated seeding, secretion and intercellular transfer through synaptic and non-synaptic pathways. The experimental findings supporting each of these steps are reviewed. The clinical validity of these experimental findings is then debated by considering the supportive or contradictory findings from patient samples. Further, the role of physiological tau release in this scenario is examined because emerging data shows that tau is secreted but the physiological function (if any) of this secretion in the context of propagation of pathological tau seeds is unclear. Bona fide prions exhibit specific properties, including transmission from cell to cell, tissue to tissue and organism to organism. The propagation of tau pathology has so far not been shown to exhibit all of these steps and how this influences the debate of whether or not abnormal tau species can propagate in a "prion-like" manner is discussed. The exact nature of tau seeds responsible for propagation of tau pathology in human tauopathies remains controversial; it might be tightly linked to the existence of tau strains stably propagating peculiar patterns of neuropathological lesions, corresponding to the different patterns seen in human tauopathies. That this is a property shared by all seed-competent tau conformers is not yet firmly established. Further investigation is also required to clarify the relationship between propagation of tau aggregates and tau-induced toxicity. Genetic variants identified as risks factors for tauopathies might play a role in propagation of tau pathology, but many more studies are needed to document this. The contribution of selective vulnerability of neuronal populations, as an alternative to prion-like mechanisms to explain spreading of tau pathology needs to be clarified. Learning from the prion field will be helpful to enhance our understanding of propagation of tau pathology. Finally, development of better models is expected to answer some of these key questions and allow for the testing of propagation-centred therapies.

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 日付: 2017-12-192017-12-19
 出版の状態: 出版
 ページ: -
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 目次: -
 査読: -
 識別子（DOI, ISBNなど）: ISI: 000418274500001
DOI: 10.1186/s40478-017-0488-7
 学位: -

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出版物 1

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出版物名: Acta Neuropathologica Communications
  省略形 : Acta Neuropathol Commun.
種別: 学術雑誌
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出版社, 出版地: -
ページ: - 巻号: 5 (1) 通巻号: 99 開始・終了ページ: - 識別子（ISBN, ISSN, DOIなど）: ISSN: 2051-5960