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  Atypical, non-standard functions of the microtubule associated Tau protein

Sotiropoulos, I., Galas, M.-C., Silva, J. M., Skoulakis, E., Wegmann, S., Maina, M. B., et al. (2017). Atypical, non-standard functions of the microtubule associated Tau protein. Acta Neuropathologica Communications, 5: 91. doi:10.1186/s40478-017-0489-6.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0001-7846-A Version Permalink: https://hdl.handle.net/21.11116/0000-0007-50CE-7
Genre: Journal Article

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https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-017-0489-6 (Publisher version)
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Open Access
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 Creators:
Sotiropoulos, Ioannis1, Author
Galas, Marie-Christine1, Author
Silva, Joana M.1, Author
Skoulakis, Efthimios1, Author
Wegmann, Susanne1, Author
Maina, Mahmoud Bukar1, Author
Blum, David1, Author
Sayas, Carmen Laura1, Author
Mandelkow, Eva-Maria1, 2, Author
Mandelkow, Eckhard1, 2, Author
Spillantini, Maria Grazia1, Author
Sousa, Nuno1, Author
Avila, Jesus1, Author
Medina, Miguel1, Author
Mudher, Amrit1, Author
Buee, Luc1, Author
Affiliations:
1external, ou_persistent22              
2Neuronal Cytoskeleton and Alzheimer's Disease, Cooperations, Center of Advanced European Studies and Research (caesar), Max Planck Society, Ludwig-Erhard-Allee 2, 53175 Bonn, DE, ou_2173677              

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 Abstract: Since the discovery of the microtubule-associated protein Tau (MAPT) over 40 years ago, most studies have focused on Tau's role in microtubule stability and regulation, as well as on the neuropathological consequences of Tau hyperphosphorylation and aggregation in Alzheimer's disease (AD) brains. In recent years, however, research efforts identified new interaction partners and different sub-cellular localizations for Tau suggesting additional roles beyond its standard function as microtubule regulating protein. Moreover, despite the increasing research focus on AD over the last decades, Tau was only recently considered as a promising therapeutic target for the treatment and prevention of AD as well as for neurological pathologies beyond AD e.g. epilepsy, excitotoxicity, and environmental stress. This review will focus on atypical, non-standard roles of Tau on neuronal function and dysfunction in AD and other neurological pathologies providing novel insights about neuroplastic and neuropathological implications of Tau in both the central and the peripheral nervous system.

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 Dates: 2017-11-292017-11-29
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: ISI: 000416751200003
DOI: 10.1186/s40478-017-0489-6
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Title: Acta Neuropathologica Communications
  Abbreviation : Acta Neuropathol Commun.
Source Genre: Journal
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Publ. Info: Biomedcentral
Pages: - Volume / Issue: 5 Sequence Number: 91 Start / End Page: - Identifier: ISSN: 2051-5960