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  Stress induces a shift towards striatum-dependent stimulus-response learning via the mineralocorticoid receptor

Vogel, S., Klumpers, F., Navarro Schröder, T., Oplaat, K. T., Krugers, H. J., Oitzl, M. S., et al. (2017). Stress induces a shift towards striatum-dependent stimulus-response learning via the mineralocorticoid receptor. Neuropsychopharmacology, 42(6), 1262-1271. doi:10.1038/npp.2016.262.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-0001-7AA5-C Versions-Permalink: https://hdl.handle.net/21.11116/0000-000A-5EF8-6
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 Urheber:
Vogel, Susanne1, Autor
Klumpers, Floris1, Autor
Navarro Schröder, Tobias 1, Autor
Oplaat, Krista T.1, Autor
Krugers, Harm J.1, Autor
Oitzl, Melly S.1, Autor
Joëls, Marian1, Autor
Doeller, Christian F.1, Autor           
Fernández, Guillén1, Autor
Affiliations:
1External Organizations, ou_persistent22              

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 Zusammenfassung: Stress is assumed to cause a shift from flexible 'cognitive' memory to more rigid 'habit' memory. In the spatial memory domain, stress impairs place learning depending on the hippocampus whereas stimulus-response learning based on the striatum appears to be improved. While the neural basis of this shift is still unclear, previous evidence in rodents points towards cortisol interacting with the mineralocorticoid receptor (MR) to affect amygdala functioning. The amygdala is in turn assumed to orchestrate the stress-induced shift in memory processing. However, an integrative study testing these mechanisms in humans is lacking. Therefore, we combined functional neuroimaging of a spatial memory task, stress-induction, and administration of an MR-antagonist in a full-factorial, randomized, placebo-controlled between-subjects design in 101 healthy males. We demonstrate that stress-induced increases in cortisol lead to enhanced stimulus-response learning, accompanied by increased amygdala activity and connectivity to the striatum. Importantly, this shift was prevented by an acute administration of the MR-antagonist spironolactone. Our findings support a model in which the MR and the amygdala play an important role in the stress-induced shift towards habit memory systems, revealing a fundamental mechanism of adaptively allocating neural resources that may have implications for stress-related mental disorders.

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Sprache(n): eng - English
 Datum: 2016-09-212015-12-102016-11-142016-11-232017-05
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1038/npp.2016.262
PMID: 27876790
PMC: PMC5437884
Anderer: Epub 2016
 Art des Abschluß: -

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Projektname : -
Grant ID : 433-09-251
Förderprogramm : -
Förderorganisation : Netherlands Organisation for Scientific Research (NWO)
Projektname : -
Grant ID : 452-12-009
Förderprogramm : Vidi-Grant
Förderorganisation : Netherlands Organisation for Scientific Research (NWO)
Projektname : The neurobiology of schemas: knowledge acquisition and consolidation / NEUROSCHEMA
Grant ID : 268800
Förderprogramm : Funding Programme 7
Förderorganisation : European Commission (EC)
Projektname : From neurons to behaviour: Context representation and memory reconsolidation in the entorhinal hippocampal system / RECONTEXT
Grant ID : 261177
Förderprogramm : Funding Programme 7
Förderorganisation : European Commission (EC)

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Titel: Neuropsychopharmacology
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: New York, NY : No longer published by Elsevier
Seiten: - Band / Heft: 42 (6) Artikelnummer: - Start- / Endseite: 1262 - 1271 Identifikator: ISSN: 0893-133X
CoNE: https://pure.mpg.de/cone/journals/resource/954925558485