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  In vivo estimation of transverse relaxation time constant (T2) of 17 human brain metabolites at 3T

Wyss, P., Bianchini, C., Scheidegger, M., Giapitzakis, I., Hock, A., Fuchs, A., et al. (2018). In vivo estimation of transverse relaxation time constant (T2) of 17 human brain metabolites at 3T. Magnetic Resonance in Medicine, 80(2), 452-461. doi:10.1002/mrm.27067.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-7C99-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-7C9A-7
Genre: Journal Article

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Wyss, PO1, 2, Author              
Bianchini, C, Author
Scheidegger, M, Author
Giapitzakis, IA1, 2, 3, Author              
Hock, A, Author
Fuchs, A, Author
Henning, A1, 2, 3, Author              
Affiliations:
1Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528692              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
3Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              

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 Abstract: Purpose The transverse relaxation times T2 of 17 metabolites in vivo at 3T is reported and region specific differences are addressed. Methods An echo-time series protocol was applied to one, two, or three volumes of interest with different fraction of white and gray matter including a total number of 106 healthy volunteers and acquiring a total number of 128 spectra. The data were fitted with the 2D fitting tool ProFit2, which included individual line shape modeling for all metabolites and allowed the T2 calculation of 28 moieties of 17 metabolites. Results The T2 of 10 metabolites and their moieties have been reported for the first time. Region specific T2 differences in white and gray matter enriched tissue occur in 16 of 17 metabolites examined including single resonance lines and coupled spin systems. Conclusion The relaxation time T2 is regions specific and has to be considered when applying tissue composition correction for internal water referencing.

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 Dates: 2018-08
 Publication Status: Published in print
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 Identifiers: DOI: 10.1002/mrm.27067
BibTex Citekey: WyssBSGHFH2018
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Title: Magnetic Resonance in Medicine
Source Genre: Journal
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Pages: - Volume / Issue: 80 (2) Sequence Number: - Start / End Page: 452 - 461 Identifier: -