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  Assessment of frequency drift on CEST MRI and dynamic correction: application to gagCEST at 7 T

Windschuh, J., Zaiss, M., Ehses, P., Lee, J., Jerschow, A., & Regatte, R. (2019). Assessment of frequency drift on CEST MRI and dynamic correction: application to gagCEST at 7 T. Magnetic Resonance in Medicine, 81(1), 573-582. doi:10.1002/mrm.27367.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-7CA7-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-930B-C
Genre: Journal Article

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Windschuh, J, Author
Zaiss, M1, 2, Author              
Ehses, P, Author              
Lee, JE, Author
Jerschow, A, Author
Regatte, RR, Author
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              

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 Abstract: Purpose To investigate the effect of a frequency drift of the static magnetic field on 3D CEST MRI based on glycosaminoglycans (GAGs) of articular cartilage at 7 T and to introduce a retrospective correction method that uses the phase images of the gradient‐echo readout. Methods Repeated gagCEST and B0 measurements were performed in a glucose model solution and in vivo in the knee joint of 3 healthy volunteers at 7 T. Phase images of the modified 3D rectangular spiral centric–reordered gradient‐echo CEST sequence were used to quantify and compensate the apparent frequency drift in repeated gagCEST measurements. Results The frequency drift of the MRI scanner strongly influences the gagCEST signal in the articular cartilage of the human knee joint. The gagCEST signal in the articular cartilage is changed by 0.18/Hz while an average drift of 0.7 ± 0.2 Hz/minute was observed. The proposed correction method can be applied retrospectively without the need of additional measurements and provides improved comparability and reproducibility for gagCEST studies. This correction method may also be of interest for other applications of CEST MRI. Conclusion Prospective or retrospective correction of the frequency drift of the MRI scanner is essential for reproducible gagCEST measurements. The proposed retrospective correction method fulfills this requirement without the need of additional measurements.

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 Dates: 2018-052019-01
 Publication Status: Published in print
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 Identifiers: DOI: 10.1002/mrm.27367
BibTex Citekey: WindschuhZELJR2018
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Title: Magnetic Resonance in Medicine
Source Genre: Journal
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Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: 81 (1) Sequence Number: - Start / End Page: 573 - 582 Identifier: ISSN: 0740-3194
CoNE: https://pure.mpg.de/cone/journals/resource/954925538149