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  Delayed increase of thrombocyte levels after a single sub-anesthetic dose of ketamine: A randomized trial

Colic, M., Woelfer, L., Colic, M., Leutritz, A., Liebe, T., Fensky, L., et al. (2018). Delayed increase of thrombocyte levels after a single sub-anesthetic dose of ketamine: A randomized trial. European Neuropsychopharmacology, 28(6), 701-709. doi:10.1016/j.euroneuro.2018.03.014.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-7CD2-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-81D4-D
Genre: Journal Article

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Colic, M, Author
Woelfer, L, Author
Colic, M, Author
Leutritz, AL, Author
Liebe, T, Author
Fensky, L, Author
Sen, ZD, Author
Li, M, Author
Hoffmann, J, Author
Kretzschmar, MA, Author
Isermann, B, Author
Walter, M1, 2, Author              
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              

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 Abstract: Recently, ketamine has been investigated as a potential antidepressant option for treatment resistant depression. Unlike traditional drugs, it yields immediate effects, most likely via increased glutamatergic transmission and synaptic plasticity. However, ketamine administration in humans is systemic and its long–term impact on blood parameters has not yet been described in clinical studies. Here we investigated potential sustained effects of ketamine administration (0.5 mg/kg ketamine racemate) on hematological and biochemical values in plasma and serum in a randomized double–blinded study. 80 healthy young participants were included and whole blood samples were collected 5 days before, and 14 days after the infusion. To assess the group effect, repeated measure analyses of co–variance (rmANCOVA) were conducted for the following blood parameters: levels of sodium, potassium, calcium, hemoglobin and number of erythrocytes, lymphocytes, and thrombocytes. RmANCOVA revealed a significant time by treatment effect on thrombocyte levels (F1, 74 = 13.54, p < 0.001, eta = 0.155), driven by an increase in the ketamine group (paired t-test, t = −3.51, df = 38, p = 0.001). Specificity of thrombocyte effect was confirmed by logistic regression, and in addition, no other coagulation parameters showed significant interaction. Moreover, the relative increase in the ketamine group was stable across sexes and not predicted by age, BMI, smoking, alcohol or drug use, and contraception. Our results describe aftereffects of sub–anesthetic ketamine administration on blood coagulation parameters, which should be considered especially when targeting psychiatric populations with relevant clinical comorbidities.

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 Dates: 2018-042018-06
 Publication Status: Published in print
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 Identifiers: DOI: 10.1016/j.euroneuro.2018.03.014
BibTex Citekey: ColicWCLLFSLHKIW2018
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Title: European Neuropsychopharmacology
  Other : Eur. Neuropsychopharmacol.
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 28 (6) Sequence Number: - Start / End Page: 701 - 709 Identifier: ISSN: 0924-977X
CoNE: /journals/resource/954925566729