English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Manipulating Hippocampal Place Cell Activity by Single-Cell Stimulation in Freely Moving Mice

Diamantaki, M., Coletta, S., Nasr, K., Zeraati, R., Laturnus, S., Berens, P., et al. (2018). Manipulating Hippocampal Place Cell Activity by Single-Cell Stimulation in Freely Moving Mice. Cell Reports, 23(1), 32-38. doi:10.1016/j.celrep.2018.03.031.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0001-7CDA-F Version Permalink: http://hdl.handle.net/21.11116/0000-0001-7FCC-C
Genre: Journal Article

Files

show Files

Locators

show
hide
Locator:
Link (Any fulltext)
Description:
-

Creators

show
hide
 Creators:
Diamantaki, M, Author
Coletta, S, Author
Nasr, K, Author
Zeraati, R1, Author              
Laturnus, S, Author
Berens, P1, Author              
Preston-Ferrer, P, Author
Burgalossi, A, Author
Affiliations:
1Werner-Reichardt Centre for Integrative Neuroscience, Tübingen, ou_persistent22              

Content

show
hide
Free keywords: -
 Abstract: Learning critically depends on the ability to rapidly form and store non-overlapping representations of the external world. In line with their postulated role in episodic memory, hippocampal place cells can undergo a rapid reorganization of their firing fields upon contextual manipulations. To explore the mechanisms underlying such global remapping, we juxtacellularly stimulated 42 hippocampal neurons in freely moving mice during spatial exploration. We found that evoking spike trains in silent neurons was sufficient for creating place fields, while in place cells, juxtacellular stimulation induced a rapid remapping of their place fields to the stimulus location. The occurrence of complex spikes was most predictive of place field plasticity. Our data thus indicate that plasticity-inducing stimuli are able to rapidly bias place cell activity, simultaneously suppressing existing place fields. We propose that such competitive place field dynamics could support the orthogonalization of the hippocampal map during global remapping.

Details

show
hide
Language(s):
 Dates: 2018-04
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1016/j.celrep.2018.03.031
BibTex Citekey: DiamantakiCNZLBPB2018
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Cell Reports
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 23 (1) Sequence Number: - Start / End Page: 32 - 38 Identifier: -