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  Metabolite-cycled STEAM and semi-LASER localization for MR spectroscopy of the human brain at 9.4T

Giapitzakis, I., Shao, T., Avdievich, N., Mekle, R., Kreis, R., & Henning, A. (2018). Metabolite-cycled STEAM and semi-LASER localization for MR spectroscopy of the human brain at 9.4T. Magnetic Resonance in Medicine, 79(4), 1841-1850. doi:10.1002/mrm.26873.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-7CDE-B Version Permalink: http://hdl.handle.net/21.11116/0000-0001-7CDF-A
Genre: Journal Article

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Giapitzakis, IA1, 2, 3, Author              
Shao, T1, 2, Author              
Avdievich, NI1, 2, 3, Author              
Mekle, R, Author
Kreis, R, Author
Henning, A1, 2, 3, Author              
Affiliations:
1Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528692              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
3Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              

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 Abstract: Purpose Metabolite cycling (MC) is an MRS technique for the simultaneous acquisition of water and metabolite spectra that avoids chemical exchange saturation transfer effects and for which water may serve as a reference signal or contain additional information in functional or diffusion studies. Here, MC was developed for human investigations at ultrahigh field. Methods MC-STEAM and MC-semi-LASER are introduced at 9.4T with an optimized inversion pulse and elaborate coil setup. Experimental and simulation results are given for the implementation of adiabatic inversion pulses for MC. The two techniques are compared, and the effect of frequency and phase correction based on the MC water spectra is evaluated. Finally, absolute quantification of metabolites is performed. Results The proposed coil configuration results in a maximum math formula of 48 μΤ in a voxel within the occipital lobe. Frequency and phase correction of single acquisitions improve signal-to-noise ratio (SNR) and linewidth, leading to high-resolution spectra. The improvement of SNR of N-acetylaspartate (SNRNAA) for frequency aligned data, acquired with MC-STEAM and MC-semi-LASER, are 37 and 30, respectively (P < 0.05). Moreover, a doubling of the SNRNAA for MC-semi-LASER in comparison with MC-STEAM is observed (P < 0.05). Concentration levels for 18 metabolites from the human occipital lobe are reported, as acquired with both MC-STEAM and MC-semi-LASER. Conclusion This work introduces a novel methodology for single-voxel MRS on a 9.4T whole-body scanner and highlights the advantages of semi-LASER compared to STEAM in terms of excitation profile. In comparison with MC-STEAM, MC-semi-LASER yields spectra with higher SNR.

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 Dates: 2018-04
 Publication Status: Published in print
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 Identifiers: DOI: 10.1002/mrm.26873
BibTex Citekey: GiapitzakisSAMKH2017
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Title: Magnetic Resonance in Medicine
Source Genre: Journal
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Pages: - Volume / Issue: 79 (4) Sequence Number: - Start / End Page: 1841 - 1850 Identifier: -