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  Nonmonotonic spatial structure of interneuronal correlations in prefrontal microcircuits

Safavi, S., Dwarakanath, A., Kapoor, V., Werner, J., Hatsopoulos, N., Logothetis, N., et al. (2018). Nonmonotonic spatial structure of interneuronal correlations in prefrontal microcircuits. Proceedings of the National Academy of Sciences of the United States of America, 115(15), E3539-E3548. doi:10.1073/pnas.1802356115.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-7CE2-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-94D5-4
Genre: Journal Article

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Safavi, S1, 2, Author              
Dwarakanath, A1, 2, Author              
Kapoor, V1, 2, Author              
Werner, J1, 2, Author              
Hatsopoulos, NG, Author
Logothetis, NK1, 2, Author              
Panagiotaropoulos, TI1, 2, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: Correlated fluctuations of single neuron discharges, on a mesoscopic scale, decrease as a function of lateral distance in early sensory cortices, reflecting a rapid spatial decay of lateral connection probability and excitation. However, spatial periodicities in horizontal connectivity and associational input as well as an enhanced probability of lateral excitatory connections in the association cortex could theoretically result in nonmonotonic correlation structures. Here, we show such a spatially nonmonotonic correlation structure, characterized by significantly positive long-range correlations, in the inferior convexity of the macaque prefrontal cortex. This functional connectivity kernel was more pronounced during wakefulness than anesthesia and could be largely attributed to the spatial pattern of correlated variability between functionally similar neurons during structured visual stimulation. These results suggest that the spatial decay of lateral functional connectivity is not a common organizational principle of neocortical microcircuits. A nonmonotonic correlation structure could reflect a critical topological feature of prefrontal microcircuits, facilitating their role in integrative processes.

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 Dates: 2018-04
 Publication Status: Published in print
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 Rev. Method: -
 Identifiers: DOI: 10.1073/pnas.1802356115
BibTex Citekey: SafaviDKWHLP2018_2
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Title: Proceedings of the National Academy of Sciences of the United States of America
  Other : Proc. Acad. Sci. USA
  Other : Proc. Acad. Sci. U.S.A.
  Other : Proceedings of the National Academy of Sciences of the USA
  Abbreviation : PNAS
Source Genre: Journal
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Publ. Info: Washington, D.C. : National Academy of Sciences
Pages: - Volume / Issue: 115 (15) Sequence Number: - Start / End Page: E3539 - E3548 Identifier: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230