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  Brain amyloid-burden and cerebrovascular disease are synergistically associated with neurometabolism in cognitively unimpaired older adults

Schreiner, S., Kirchner, T., Narkhede, A., Wyss, M., Van Bergen, J., Steininger, S., et al. (2018). Brain amyloid-burden and cerebrovascular disease are synergistically associated with neurometabolism in cognitively unimpaired older adults. Neurobiology of Aging, 63, 152-161. doi:10.1016/j.neurobiolaging.2017.12.004.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-7CF0-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-7CF1-4
Genre: Journal Article

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Schreiner, SJ, Author
Kirchner, T, Author
Narkhede, A, Author
Wyss, M, Author
Van Bergen, JMG, Author
Steininger, SC, Author
Gietl, A, Author
Leh, SE, Author
Treyer, V, Author
Buck, A, Author
Pruessmann, KP, Author
Nitsch, RM, Author
Hock, C, Author
Henning, A1, 2, 3, Author              
Brickman, AM, Author
Unschuld, PG, Author
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528692              
3Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              

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 Abstract: Alzheimer's disease (AD) is the most common cause for cognitive dysfunction at high age. In AD, pathological hallmarks such as beta-amyloid (Aß) aggregation and also neurometabolic change, as indicated by altered myo-inositol (mI) and N-acetylaspartate (NAA) levels, typically precede manifestation of cognitive dysfunction by years. While cerebrovascular disease occurs at earliest stages of AD pathogenesis, the interplay between vascular and neurometabolic brain change is largely unknown. Thirty cognitively normal elderly persons (age=70±5.6 years, MMSE=29.2±1) received 11-C-Pittsburgh Compound B PET for estimating Aß-plaque density, 7 Tesla (7T) fluid-attenuated inversion recovery MRI for quantifying white matter hyperintensity volume, and high-resolution FIDLOVS-based magnetic resonance spectroscopic imaging (MRSI) at 7T to investigate tissue-specific neurometabolism in the posterior cingulate and precuneus (PCP). Beta-amyloid (ß=0.45, p=0.018) and white matter hyperintensities (ß=0.40, p=0.046) were independently and interactively (ß= -0.49, p=0.026) associated with a higher ratio of mI over NAA (mI/NAA) in PCP gray matter but not in white matter. Our data suggest that cerebrovascular disease and Aß burden are synergistically related to AD-related gray matter neurometabolism at high age.

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 Dates: 2018-03
 Publication Status: Published in print
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 Identifiers: DOI: 10.1016/j.neurobiolaging.2017.12.004
BibTex Citekey: SchreinerKNWVSGLTBPNHHBU2017_2
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Title: Neurobiology of Aging
Source Genre: Journal
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Pages: - Volume / Issue: 63 Sequence Number: - Start / End Page: 152 - 161 Identifier: -