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  PRO-QUEST: a rapid assessment method based on progressive saturation for quantifying exchange rates using saturation times in CEST

Demetriou, E., Tachrount, M., Zaiss, M., Shmueli, K., & Golay, X. (2018). PRO-QUEST: a rapid assessment method based on progressive saturation for quantifying exchange rates using saturation times in CEST. Magnetic Resonance in Medicine, 80(4), 1638-1654. doi:10.1002/mrm.27155.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-7CF2-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-ED1A-8
Genre: Journal Article

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Demetriou, E, Author
Tachrount, M, Author
Zaiss, M1, 2, Author              
Shmueli, K, Author
Golay, X, Author
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              

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 Abstract: Purpose To develop a new MRI technique to rapidly measure exchange rates in CEST MRI. Methods A novel pulse sequence for measuring chemical exchange rates through a progressive saturation recovery process, called PRO-QUEST (progressive saturation for quantifying exchange rates using saturation times), has been developed. Using this method, the water magnetization is sampled under non-steady-state conditions, and off-resonance saturation is interleaved with the acquisition of images obtained through a Look-Locker type of acquisition. A complete theoretical framework has been set up, and simple equations to obtain the exchange rates have been derived. Results A reduction of scan time from 58 to 16 minutes has been obtained using PRO-QUEST versus the standard QUEST. Maps of both T1 of water and B1 can simply be obtained by repetition of the sequence without off-resonance saturation pulses. Simulations and calculated exchange rates from experimental data using amino acids such as glutamate, glutamine, taurine, and alanine were compared and found to be in good agreement. The PRO-QUEST sequence was also applied on healthy and infarcted rats after 24 hours, and revealed that imaging specificity to ischemic acidification during stroke was substantially increased relative to standard amide proton transfer–weighted imaging. Conclusion Because of the reduced scan time and insensitivity to nonchemical exchange factors such as direct water saturation, PRO-QUEST can serve as an excellent alternative for researchers and clinicians interested to map pH changes in vivo.

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 Dates: 2018-032018-10
 Publication Status: Published in print
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 Identifiers: DOI: 10.1002/mrm.27155
BibTex Citekey: DemetriouTZSG2018
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Title: Magnetic Resonance in Medicine
Source Genre: Journal
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Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: 80 (4) Sequence Number: - Start / End Page: 1638 - 1654 Identifier: ISSN: 0740-3194
CoNE: /journals/resource/954925538149