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  Flip-angle based ratiometric approach for pulsed CEST-MRI pH imaging

Arena, C., Irrera, P., Consolino, L., Colombo Serra, S., Zaiss, M., & Longo, D. (2018). Flip-angle based ratiometric approach for pulsed CEST-MRI pH imaging. Journal of Magnetic Resonance, 287, 1-9. doi:10.1016/j.jmr.2017.12.007.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-7D10-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-7D11-0
Genre: Journal Article

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Arena, C, Author
Irrera, P, Author
Consolino, L, Author
Colombo Serra, S, Author
Zaiss, M1, 2, Author              
Longo, DL, Author
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              

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 Abstract: Several molecules have been exploited for developing MRI pH sensors based on the chemical exchange saturation transfer (CEST) technique. A ratiometric approach, based on the saturation of two exchanging pools at the same saturation power, or by varying the saturation power levels on the same pool, is usually needed to rule out the concentration term from the pH measurement. However, all these methods have been demonstrated by using a continuous wave saturation scheme that limits its translation to clinical scanners. This study shows a new ratiometric CEST-MRI pH-mapping approach based on a pulsed CEST saturation scheme for a radiographic contrast agent (iodixanol) possessing a single chemical exchange site. This approach is based on the ratio of the CEST contrast effects at two different flip angles combinations (180°/360° and 180°/720°), keeping constant the mean irradiation RF power (Bavg power). The proposed ratiometric approach index is concentration independent and it showed good pH sensitivity and accuracy in the physiological range between 6.0 and 7.4.

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 Dates: 2018-02
 Publication Status: Published in print
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 Identifiers: DOI: 10.1016/j.jmr.2017.12.007
BibTex Citekey: ArenaICCZL2017
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Title: Journal of Magnetic Resonance
Source Genre: Journal
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Pages: - Volume / Issue: 287 Sequence Number: - Start / End Page: 1 - 9 Identifier: -