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  Mapping the functional recovery of brainstem injury-induced comatose rats with eigenvector-centrality mapping and seed-based analysis of resting-state fMRI

Pais Roldan, P., Edlow, B., Stelzer, J., Jiang, Y., & Yu, X. (2018). Mapping the functional recovery of brainstem injury-induced comatose rats with eigenvector-centrality mapping and seed-based analysis of resting-state fMRI. Poster presented at Joint Annual Meeting ISMRM-ESMRMB 2018, Paris, France.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-7D6D-A Version Permalink: http://hdl.handle.net/21.11116/0000-0001-936E-E
Genre: Poster

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Pais Roldan, P1, 2, Author              
Edlow, B, Author
Stelzer, J2, 3, Author              
Jiang, Y1, 2, Author              
Yu, X1, 2, Author              
Affiliations:
1Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528695              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
3Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              

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 Abstract: Here we used the rat brainstem coma model and rs-fMRI to systematically study the network dynamics during recovery from coma. Using whole brain connectivity analysis we obtained connectivity slope maps from the comatose animals, which revealed the brain regions with higher connectivity changes. In parallel, we performed a seed-based analysis to specify the strengthened connections between ROIs. Both methods indicated an increase in the connectivity between basal forebrain, basal ganglia and thalamus, along the acute phase of recovery from coma. These parallel analyses applied to comatose rats provided new insights into the regulations occurring during recovery of consciousness.

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 Dates: 2018-06
 Publication Status: Published in print
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 Identifiers: BibTex Citekey: PaisRoldanESJY2018
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Title: Joint Annual Meeting ISMRM-ESMRMB 2018
Place of Event: Paris, France
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Title: Joint Annual Meeting ISMRM-ESMRMB 2018
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 5539 Start / End Page: - Identifier: -